Targeted protein degradation (TPD) has emerged as an exciting new era in chemical
biology and drug discovery. PROteolysis TArgeting Chimera (PROTAC) technology targets …

Proteasomes are large, multicatalytic protein complexes that cleave cellular proteins into
peptides. There are many distinct forms of proteasomes that differ in catalytically active …

Parkinson's disease (PD) is the second most common neurodegenerative disorder
worldwide, mainly affecting the elderly. The disease progresses gradually, with core motor …

Ubiquitination is the major criteria for the recognition of a substrate-protein by the 26S
proteasome. Additionally, a disordered segment on the substrate—either intrinsic or induced …

Mature red blood cells (RBCs) lack internal organelles and canonical defense mechanisms,
making them both a fascinating host cell, in general, and an intriguing choice for the deadly …

Controlled degradation of proteins is necessary for ensuring their abundance and sustaining
a healthy and accurately functioning proteome. One of the degradation routes involves the …

Proteasomes are multisubunit complexes that catalyze the majority of protein degradation in
mammalian cells to maintain protein homeostasis and influence the regulation of most …

The homeostasis of cellular proteins, or proteostasis, is critical for neuronal function and for
brain processes, including learning and memory. Increasing evidence indicates that …

Neurons continuously adapt to external cues and challenges, including stimulation, plasticity-
inducing signals and aging. These adaptations are critical for neuronal physiology and …

For years, proteasomal degradation was predominantly attributed to the ubiquitin-26S
proteasome pathway. However, it is now evident that the core 20S proteasome can …