Transcription factor nuclear factor erythroid 2‐related factor 2 (Nrf2) is a major regulator of
antioxidant response element‐(ARE‐) driven cytoprotective protein expression. The …

Activated macrophages play a central role in both the development and resolution of
inflammation. These immune cells need to be functional in harmful conditions with high …

The transcription factor NRF2 and its endogenous inhibitor KEAP1 play a crucial role in the
maintenance of cellular redox homeostasis by regulating the gene expression of diverse …

Specialized proresolving mediators (SPMs) are a novel class of endogenous lipids, derived
by ω‐6 and ω‐3 essential polyunsaturated fatty acids such as arachidonic acid (AA) …

Lipid metabolism plays an important role in many lung functions. Disorders of lipid
metabolism are part of the pathogenesis of chronic obstructive pulmonary disease (COPD) …

Polyunsaturated fatty acids (PUFA) are fundamental building materials for cells and play
crucial function as signaling molecules. When PUFA are used as substrates for non …

Specialized pro-resolving mediators (SPMs) are endogenous small molecules produced
mainly from dietary omega-3 polyunsaturated fatty acids by both structural cells and cells of …

Respiratory diseases include a wide range of pathologies with different clinical
manifestations, affecting the normal airways and lung function. An increase in the …

Although historically pre‐eclampsia, preterm birth, abruption, fetal growth restriction and
stillbirth have been viewed as clinically distinct entities, a growing body of literature has …

Despite numerous studies on the mechanisms of cigarette smoking toxicity over the past
three decades, some aspects remain obscure. Recent developments have drawn attention …