Hematopoietic stem cell factors: their functional role in self-renewal and clinical aspects
Z Mann, M Sengar, YK Verma, R Rajalingam… - Frontiers in Cell and …, 2022 - frontiersin.org
Hematopoietic stem cells (HSCs) possess two important properties such as self-renewal and
differentiation. These properties of HSCs are maintained through hematopoiesis. This …
differentiation. These properties of HSCs are maintained through hematopoiesis. This …
Endothelial-specific cre mouse models: is your cre credibile?
S Payne, S De Val, A Neal - Arteriosclerosis, thrombosis, and …, 2018 - Am Heart Assoc
The field of vascular biology has gained enormous insight from the use of Cre and inducible
Cre mouse models to temporally and spatially manipulate gene expression within the …
Cre mouse models to temporally and spatially manipulate gene expression within the …
Characteristics of blood–brain barrier heterogeneity between brain regions revealed by profiling vascular and perivascular cells
The blood–brain barrier (BBB) protects the brain and maintains neuronal homeostasis. BBB
properties can vary between brain regions to support regional functions, yet how BBB …
properties can vary between brain regions to support regional functions, yet how BBB …
Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models
Cytotoxic chemotherapy is an effective treatment for invasive breast cancer. However,
experimental studies in mice also suggest that chemotherapy has pro-metastatic effects …
experimental studies in mice also suggest that chemotherapy has pro-metastatic effects …
An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex
The major cell classes of the brain differ in their developmental processes, metabolism,
signaling, and function. To better understand the functions and interactions of the cell types …
signaling, and function. To better understand the functions and interactions of the cell types …
Regional blood flow in the normal and ischemic brain is controlled by arteriolar smooth muscle cell contractility and not by capillary pericytes
The precise regulation of cerebral blood flow is critical for normal brain function, and its
disruption underlies many neuropathologies. The extent to which smooth muscle-covered …
disruption underlies many neuropathologies. The extent to which smooth muscle-covered …
Post-capillary venules are the key locus for transcytosis-mediated brain delivery of therapeutic nanoparticles
Effective treatments of neurodegenerative diseases require drugs to be actively transported
across the blood-brain barrier (BBB). However, nanoparticle drug carriers explored for this …
across the blood-brain barrier (BBB). However, nanoparticle drug carriers explored for this …
Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels
Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour
blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to …
blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to …
Lactate induces vascular permeability via disruption of VE-cadherin in endothelial cells during sepsis
Circulating lactate levels are a critical biomarker for sepsis and are positively correlated with
sepsis-associated mortality. We investigated whether lactate plays a biological role in …
sepsis-associated mortality. We investigated whether lactate plays a biological role in …
Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells
Vascular endothelial cell (EC) function depends on appropriate organ-specific molecular
and cellular specializations. To explore genomic mechanisms that control this specialization …
and cellular specializations. To explore genomic mechanisms that control this specialization …