The expression of mitochondrial genes is regulated in response to the metabolic needs of
different cell types, but the basic mechanisms underlying this process are still poorly …

The mitochondrial genome encodes core subunits of the respiratory chain that drives
oxidative phosphorylation and is, therefore, essential for energy conversion. Advances in …

The human mitochondrial genome must be replicated and expressed in a timely manner to
maintain energy metabolism and supply cells with adequate levels of adenosine …

Mitochondria have their own DNA (mtDNA), which is susceptible to the accumulation of
disease-causing mutations. To prevent deleterious mutations from being inherited, the …

Cancer is characterized by abnormal cell differentiation in or on the part of the body. The
most commonly used chemotherapeutic drugs are developed to target rapidly dividing cells …

As one of the most common gynecologic malignant tumors, ovarian cancer is usually
diagnosed at an advanced and incurable stage because of its early asymptomatic onset …

Background Transforming growth factor β regulator 4 (TBRG4) is a potential prognostic
indicator in various cancers, especially squamous cell carcinomas, and is associated with …

The human mitochondrial genome encodes crucial oxidative phosphorylation system
proteins, pivotal for aerobic energy transduction. They are translated from nine …

In human cells, the nuclear and mitochondrial genomes engage in a complex interplay to
produce dual-encoded oxidative phosphorylation (OXPHOS) complexes. The coordination …

Canonical RNA processing in mammalian mitochondria is defined by tRNAs acting as
recognition sites for nucleases to release flanking transcripts. The relevant factors, their …