Bench-to-bedside: Innovation of small molecule anti-SARS-CoV-2 drugs in China
L Yang, Z Wang - European journal of medicinal chemistry, 2023 - Elsevier
The ongoing COVID-19 pandemic has resulted in millions of deaths globally, highlighting
the need to develop potent prophylactic and therapeutic strategies against SARS-CoV-2 …
the need to develop potent prophylactic and therapeutic strategies against SARS-CoV-2 …
Small molecules in the treatment of COVID-19
S Lei, X Chen, J Wu, X Duan, K Men - Signal transduction and targeted …, 2022 - nature.com
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …
societies and economies. Until now, effective therapeutics against COVID-19 are in high …
Natural products, alone or in combination with FDA-approved drugs, to treat COVID-19 and lung cancer
L Yang, Z Wang - Biomedicines, 2021 - mdpi.com
As a public health emergency of international concern, the highly contagious coronavirus
disease 2019 (COVID-19) pandemic has been identified as a severe threat to the lives of …
disease 2019 (COVID-19) pandemic has been identified as a severe threat to the lives of …
Comparison of viral RNA–host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2
In contrast to the extensive research about viral protein–host protein interactions that has
revealed major insights about how RNA viruses engage with host cells during infection, few …
revealed major insights about how RNA viruses engage with host cells during infection, few …
An investigation on the molecular structure, interaction with metal clusters, anti-Covid-19 ability of 2-deoxy-D-glucose: DFT calculations, MD and docking simulations
Studies of the geometrical, vibration, absorption and physicochemical properties of 2-deoxy-
D-glucose with and without metal clusters are reported using the DFT method. 2-Deoxy-D …
D-glucose with and without metal clusters are reported using the DFT method. 2-Deoxy-D …
[HTML][HTML] Advances in the development of therapeutic strategies against COVID-19 and perspectives in the drug design for emerging SARS-CoV-2 variants
J Yin, C Li, C Ye, Z Ruan, Y Liang, Y Li, J Wu… - Computational and …, 2022 - Elsevier
Abstract Since Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was
identified in late 2019, the coronavirus disease 2019 (COVID-19) pandemic has challenged …
identified in late 2019, the coronavirus disease 2019 (COVID-19) pandemic has challenged …
[HTML][HTML] Protein structure-based in-silico approaches to drug discovery: Guide to COVID-19 therapeutics
With more than 5 million fatalities and close to 300 million reported cases, COVID-19 is the
first documented pandemic due to a coronavirus that continues to be a major health …
first documented pandemic due to a coronavirus that continues to be a major health …
Efficient disinfection of SARS-CoV-2-like coronavirus, pseudotyped SARS-CoV-2 and other coronaviruses using cold plasma induces spike protein damage
H Qin, H Qiu, ST He, B Hong, K Liu, F Lou, M Li… - Journal of hazardous …, 2022 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) has become a worldwide public health
emergency, and the high transmission of SARS-CoV-2 variants has raised serious concerns …
emergency, and the high transmission of SARS-CoV-2 variants has raised serious concerns …
[HTML][HTML] SARS-CoV2 infection impairs the metabolism and redox function of cellular glutathione
Viral infections sustain their replication cycle promoting a pro-oxidant environment in the
host cell. In this context, specific alterations of the levels and homeostatic function of the …
host cell. In this context, specific alterations of the levels and homeostatic function of the …
Drug combinations as a first line of defense against coronaviruses and other emerging viruses
The world was unprepared for coronavirus disease 2019 (COVID-19) and remains ill-
equipped for future pandemics. While unprecedented strides have been made developing …
equipped for future pandemics. While unprecedented strides have been made developing …