Calcium-permeable ion channels in pain signaling

E Bourinet, C Altier, ME Hildebrand… - Physiological …, 2014 - journals.physiology.org
The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

L-Type CaV1.2 Calcium Channels: From In Vitro Findings to In Vivo Function

F Hofmann, V Flockerzi, S Kahl… - Physiological …, 2014 - journals.physiology.org
The L-type Cav1. 2 calcium channel is present throughout the animal kingdom and is
essential for some aspects of CNS function, cardiac and smooth muscle contractility …

Role of hippocampal Cav1. 2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory

S Moosmang, N Haider, N Klugbauer… - Journal of …, 2005 - Soc Neuroscience
Current knowledge about the molecular mechanisms of NMDA receptor (NMDAR)-
independent long-term potentiation (LTP) in the hippocampus and its function for memory …

[HTML][HTML] AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling

SF Oliveria, ML Dell'Acqua, WA Sather - Neuron, 2007 - cell.com
Neuronal L-type calcium channels contribute to dendritic excitability and activity-dependent
changes in gene expression that influence synaptic strength. Phosphorylation-mediated …

The role of metaplasticity mechanisms in regulating memory destabilization and reconsolidation

PSB Finnie, K Nader - Neuroscience & Biobehavioral Reviews, 2012 - Elsevier
Memory allows organisms to predict future events based on prior experiences. This requires
encoded information to persist once important predictors are extracted, while also being …

[HTML][HTML] The extracellular matrix molecule hyaluronic acid regulates hippocampal synaptic plasticity by modulating postsynaptic L-type Ca2+ channels

G Kochlamazashvili, C Henneberger, O Bukalo… - Neuron, 2010 - cell.com
Although the extracellular matrix plays an important role in regulating use-dependent
synaptic plasticity, the underlying molecular mechanisms are poorly understood. Here we …

The role of L-type voltage-gated calcium channels Cav1.2 and Cav1.3 in normal and pathological brain function

SM Berger, D Bartsch - Cell and tissue research, 2014 - Springer
The use of specific activators and inhibitors that penetrate the central nervous system has
suggested an essential functional role of L-type calcium channels (LTCC) in several …

[HTML][HTML] Isoform-specific regulation of mood behavior and pancreatic β cell and cardiovascular function by L-type Ca2+ channels

MJ Sinnegger-Brauns, A Hetzenauer… - The Journal of …, 2004 - Am Soc Clin Investig
Cav1. 2 and Cav1. 3 L-type Ca2+ channels (LTCCs) are believed to underlie Ca2+ currents
in brain, pancreatic β cells, and the cardiovascular system. In the CNS, neuronal LTCCs …

Expression and 1, 4-dihydropyridine-binding properties of brain L-type calcium channel isoforms

MJ Sinnegger-Brauns, IG Huber, A Koschak… - Molecular …, 2009 - ASPET
The L-type calcium channel (LTCC) isoforms Cav1. 2 and Cav1. 3 display similar 1, 4-
dihydropyridine (DHP) binding properties and are both expressed in mammalian brain …

[HTML][HTML] From gene to behavior: L-type calcium channel mechanisms underlying neuropsychiatric symptoms

ZD Kabir, A Martínez-Rivera, AM Rajadhyaksha - Neurotherapeutics, 2017 - Elsevier
The L-type calcium channels (LTCCs) Ca v 1.2 and Ca v 1.3, encoded by the CACNA1C
and CACNA1D genes, respectively, are important regulators of calcium influx into cells and …