Succinate is a circulating metabolite, and the relationship between abnormal changes in the
physiological concentration of succinate and inflammatory diseases caused by the …

Metabolites are intermediate products of cellular metabolism catalysed by various enzymes.
Metabolic remodelling, as a biochemical fingerprint of cancer cells, causes abnormal …

Succinate is a tricarboxylic acid (TCA) cycle intermediate normally confined to the
mitochondrial matrix. It is a substrate of succinate dehydrogenase (SDH). Mutation of SDH …

Succinate dehydrogenase (SDH) loss-of-function mutations drive succinate accumulation in
tumor microenvironments, for example in the neuroendocrine tumors pheochromocytoma …

Mitochondrial complex II is traditionally studied for its participation in two key respiratory
processes: the electron transport chain and the Krebs cycle. There is now a rich body of …

Research focused on succinate dehydrogenase (SDH) and its substrate, succinate,
culminated in the 1950s accompanying the rapid development of research dedicated to …

Abstract Background Mitochondrial complex ΙΙ has a unique biological role owing to its
participation in both the citric acid cycle and the electron transport chain. Our goal was to …

Abstract Angiotensin (Ang)-(1–7) stimulates vasoprotective functions of diabetic (DB) CD34+
hematopoietic stem/progenitor cells partly by decreasing reactive oxygen species (ROS) …

Cancer cells display metabolic alterations to meet the bioenergetic demands for their high
proliferation rates. Succinate is a central metabolite of the tricarboxylic acid (TCA) cycle, but …

Pheochromocytomas and paragangliomas continue to be defined by significant morbidity
and mortality despite their several recent advances in diagnosis, localization, and …