Exosomes are a subgroup of nanosized extracellular vesicles enclosed by a lipid bilayer
membrane and secreted by most eukaryotic cells. They represent a route of intercellular …

The field of extracellular vesicle (EV) research has developed rapidly over the last decade
from the study of fundamental biology to a subject of significant clinical relevance. The …

Extracellular-vesicle-based cell-to-cell communication is conserved across all kingdoms of
life. There is compelling evidence that extracellular vesicles are involved in major (patho) …

The term 'extracellular vesicles' refers to a heterogeneous population of vesicular bodies of
cellular origin that derive either from the endosomal compartment (exosomes) or as a result …

Exosomes are cell-secreted nanoparticles (generally with a size of 30–150 nm) bearing
numerous biological molecules including nucleic acids, proteins and lipids, which are …

Cancer-derived extracellular vesicles (EVs) are regarded as having promising potential to
be used as therapeutics and disease biomarkers. Mechanistically, EVs have been shown to …

Extracellular vesicles are released by the majority of cell types and circulate in body fluids.
They function as a long-distance cell-to-cell communication mechanism that modulates the …

Over the past decades, a multitude of synthetic drug delivery systems has been developed
and introduced to the market. However, applications of such systems are limited due to …

Extracellular vesicles (EVs) have emerged as a novel cell‐free strategy for the treatment of
many diseases including cancer. As a result of their natural properties to mediate cell‐to‐cell …

Abstract Background 5-Fluorouracil (5-FU) has been commonly prescribed for patients with
colorectal cancer (CRC), but resistance to 5-FU is one of the main reasons for failure in …