Comparison of the PF07598-Encoded Virulence-Modifying Proteins of L. interrogans and L. borgpetersenii

DS Vieira, R Chaurasia, JM Vinetz - Tropical Medicine and Infectious …, 2022 - mdpi.com
Leptospirosis is an emerging infectious disease, with increasing frequency and severity of
outbreaks, a changing epidemiology of populations at risk, and the emergence of new …

CRISPR-prime editing, a versatile genetic tool to create specific mutations with a single nucleotide resolution in Leptospira

LGV Fernandes, C Hamond, BW Tibbs-Cortes, EJ Putz… - Mbio, 2024 - journals.asm.org
Leptospirosis, caused by pathogenic bacteria from the genus Leptospira, is a global
zoonosis responsible for more than one million human cases and 60,000 deaths annually …

[HTML][HTML] Investigations into the growth and formation of biofilm by Leptospira biflexa at temperatures encountered during infection

P dos Santos Ribeiro, J Stasko, A Shircliff… - Biofilm, 2025 - Elsevier
The genus Leptospira comprises unique atypical spirochete bacteria that includes the
etiological agent of leptospirosis, a globally important zoonosis. Biofilms are …

Identification of equine mares as reservoir hosts for pathogenic species of Leptospira

C Hamond, EN Adam, NE Stone, K LeCount… - Frontiers in Veterinary …, 2024 - frontiersin.org
Equine leptospirosis can result in abortion, stillbirth, neonatal death, placentitis, and uveitis.
Horses can also act as subclinical reservoir hosts of infection, which are characterized as …

Proteomic profiles of Leptospira borgpetersenii serovar Hardjo strains JB197 and HB203 cultured at different temperatures

EJ Putz, LGV Fernandes, KMS Davila, J Whitelegge… - Journal of …, 2024 - Elsevier
Leptospirosis is a global zoonotic disease affecting humans, domestic, and wild animals.
Leptospira are typically shed in the urine of reservoir hosts which persist in suitable …

DMEM and EMEM are suitable surrogate media to mimic host environment and expand leptospiral pathogenesis studies using in vitro tools

L Garcia, Z Lin, S Culos, MC Muenker, EE Johnson… - bioRxiv, 2025 - biorxiv.org
Pathogenic Leptospira species can survive and thrive in a wide range of environments.
Distinct environments expose the bacteria to different temperatures, osmolarities, and …

A New Recombinant Multiepitope Chimeric Protein of Leptospira interrogans Is a Promising Marker for the Serodiagnosis of Leptospirosis

LGV Fernandes, KES Avelar, EC Romero… - Tropical Medicine and …, 2022 - mdpi.com
The zoonotic disease leptospirosis is caused by pathogenic species of the genus Leptospira
and was recently included in the list of Neglected Diseases by the World Health …