Obesity is associated with many adverse health effects, such as an increased
cardiometabolic risk. Despite higher adiposity for a given BMI, premenopausal women are at …

The current obesity epidemic poses a major public health issue since obesity predisposes
towards several chronic diseases. BMI and total adiposity are positively correlated with …

Insulin resistance is a key mediator of obesity-related cardiometabolic disease, yet the
mechanisms underlying this link remain obscure. Using an integrative genomic approach …

A new cardiometabolic-based chronic disease (CMBCD) model is presented that provides a
basis for early and sustainable, evidence-based therapeutic targeting to promote …

The distribution of adipose tissue in the body has wide-ranging and reproducible
associations with health and disease. Accumulation of adipose tissue in the upper body …

Adipose tissue is a highly heterogeneous endocrine organ. The heterogeneity among
different anatomical depots stems from their intrinsic differences in cellular and physiological …

There has been an alarming increase in the prevalence of obesity in people with type 1
diabetes in recent years. Although obesity has long been recognized as a major risk factor …

Genome-wide association studies have implicated around 250 genomic regions in
predisposition to type 2 diabetes, with evidence for causal variants and genes emerging for …

Lipedema is a chronic progressive disease characterized by abnormal fat distribution
resulting in disproportionate, painful limbs. It almost exclusively affects women, leading to …

Obesity is strongly associated with metabolic syndrome. Recent research suggests that
excess adipose tissue plays an important role in development of the syndrome. On the other …