Abstract The Catalogue of Somatic Mutations in Cancer (COSMIC) Cancer Gene Census
(CGC) is an expert-curated description of the genes driving human cancer that is used as a …

The cytokine IL-7 and its receptor, IL-7R, are critical for T cell and, in the mouse, B cell
development, as well as differentiation and survival of naive T cells, and generation and …

T cell acute lymphoblastic leukaemia (T-ALL) is an aggressive haematological malignancy
derived from early T cell progenitors. In recent years genomic and transcriptomic studies …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy caused by the
accumulation of genomic lesions that affect the development of T cells. For many years, it …

T-cell acute lymphoblastic leukemias (T-ALL) are immature lymphoid tumors localizing in the
bone marrow, mediastinum, central nervous system, and lymphoid organs. They account for …

T-cell acute lymphoblastic leukemia (T-ALL) accounts for 15% and 25% of total childhood
and adult ALL cases, respectively. During T-ALL, patients are at risk of organ infiltration by …

Tight regulation of IL-7Rα expression is essential for normal T-cell development. IL-7Rα gain-
of-function mutations are known drivers of T-cell acute lymphoblastic leukemia (T-ALL) …

Next-generation sequencing has provided a detailed overview of the various genomic
lesions implicated in the pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) …

Chemoresistance is a major cause of recurrence and death from T-cell acute lymphoblastic
leukemia (T-ALL), both in adult and pediatric patients. In the majority of cases, drug-resistant …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease caused by the
malignant transformation of immature progenitors primed towards T-cell development …