Glaucoma, the world's leading cause of irreversible blindness, is a complex disease, with
differential presentation as well as ethnic and geographic disparities. The multifactorial …

PEX-associated genes are beginning to reveal relevant biological pathways and processes
involved in disease development. To understand the functional consequences and …

Caveolae, specialized plasma membrane invaginations present in most cell types, play
important roles in multiple cellular processes including cell signaling, lipid uptake and …

Background and aims Lysyl oxidase-like-1 (LOXL1), a vital cross-linking enzyme in
extracellular matrix (ECM) maintenance, promotes fibrosis via enhancement of ECM …

Glaucoma refers to a heterogenous group of disorders characterised by progressive loss of
retinal ganglion cells and associated visual field loss. Both early‐onset and adult‐onset …

Pseudoexfoliation syndrome (PEXS) is a systemic disease caused by defects in the
extracellular matrix (ECM) remodelling process leading to the chronic deposition of …

Pseudoexfoliation syndrome (PEXS) is an age‐related condition manifesting mainly in
ocular tissues. PEXS is manifested through excess aggregation of fibrillary extracellular …

Lysyl oxidase-like 1 encoded by the LOXL1 gene is a member of the lysyl oxidase family of
enzymes that are important in the maintenance of extracellular matrix (ECM)-rich tissue …

Pseudoexfoliation syndrome (PEX) is a systemic, age-related disorder characterized by
elastosis and extracellular matrix deposits. Its most significant ocular manifestation is an …

Modeling complex eye diseases like age-related macular degeneration (AMD) and
glaucoma poses significant challenges, since these conditions depend highly on age …