Introduction: Hypoxic tumors overexpress two carbonic anhydrases (CA, EC 4.2. 1.1), CA IX
and XII, involved in complex processes connected to tumorigenesis (pH regulation …

Human carbonic anhydrase (CA) IX is a tumor‐associated protein, since it is scarcely
present in normal tissues, but highly overexpressed in a large number of solid tumors, where …

Hypoxia and acidosis are salient features of many tumors, leading to a completely different
metabolism compared to normal cells. Two of the simplest metabolic products, protons and …

We report here a new drug design strategy for producing membrane-impermeant carbonic
anhydrase (CA; EC 4.2. 1.1) inhibitors selectively targeting the tumor-associated, membrane …

Cancer cells rely on the enzyme telomerase (EC 2.7. 7.49) to promote cellular immortality.
Telomerase inhibitors (ie, azidothymidine) can represent promising antitumor agents …

Carbonic anhydrases (CAs) are ubiquitous enzymes that catalyze the reversible carbon
dioxide hydration reaction. Among the eight different CA classes existing in nature, the α …

Introduction: In all living species, pH regulation is a tightly controlled process, with a plethora
of proteins involved in its regulation. These include sodium-proton exchangers, carbonic …

The human carbonic anhydrase IX (CA IX) is a hypoxia-induced transmembrane protein
belonging to the α-CA enzyme family. It has a crucial role in pH regulation in hypoxic cells …

Human carbonic anhydrases IX (hCA IX) and XII (hCA XII) are two proteins associated with
tumor formation and development. These enzymes have been largely investigated both from …

Abstract hCA IX is a multi-domain protein belonging to the family of hCAs which are
ubiquitous zinc enzymes that catalyze the reversible hydration of CO 2 to HCO 3− and H+ …