Eosinophil–lymphocyte interactions in the tumor microenvironment and cancer immunotherapy

S Grisaru-Tal, ME Rothenberg, A Munitz - Nature immunology, 2022 - nature.com
Eosinophils are important effector cells and therapeutic targets in allergic diseases.
Emerging data indicate that eosinophils infiltrate a variety of solid tumor types and have …

Eosinophils in the tumor microenvironment: implications for cancer immunotherapy

S Ghaffari, N Rezaei - Journal of Translational Medicine, 2023 - Springer
Despite being an integral part of the immune response in the tumor microenvironment
(TME), few studies have mechanistically elucidated eosinophil functions in cancer …

Spatial adaptation of eosinophils and their emerging roles in homeostasis, infection and disease

IC Arnold, A Munitz - Nature Reviews Immunology, 2024 - nature.com
Eosinophils are bone marrow-derived granulocytes that are traditionally associated with
type 2 immune responses, such as those that occur during parasite infections and allergy …

CAR T-cell therapies in China: rapid evolution and a bright future

Y Hu, J Feng, T Gu, L Wang, Y Wang, L Zhou… - The Lancet …, 2022 - thelancet.com
Chimeric antigen receptor (CAR) T-cell therapies have achieved remarkable success in the
treatment of haematological malignancies. Over the past 9 years, the use of CAR T-cell …

Challenges and Future Perspectives in Modeling Neurodegenerative Diseases Using Organ‐on‐a‐Chip Technology

FM Pramotton, S Spitz, RD Kamm - Advanced Science, 2024 - Wiley Online Library
Neurodegenerative diseases (NDDs) affect more than 50 million people worldwide, posing
a significant global health challenge as well as a high socioeconomic burden. With aging …

Insight into cancer immunity: MHCs, immune cells and commensal microbiota

M Wen, Y Li, X Qin, B Qin, Q Wang - Cells, 2023 - mdpi.com
Cancer cells circumvent immune surveillance via diverse strategies. In accordance, a large
number of complex studies of the immune system focusing on tumor cell recognition have …

Immunity and breast cancer: focus on eosinophils

A Poncin, CE Onesti, C Josse, D Boulet, J Thiry… - Biomedicines, 2021 - mdpi.com
The role of eosinophils, a cell type involved in the immune response to parasitic infections
and allergies, has been investigated in different cancer types, in both tumor tissue and at the …

CCL11/CCR3-dependent eosinophilia alleviates malignant pleural effusions and improves prognosis

M Zhang, L Xia, W Peng, G Xie, F Li, C Zhang… - NPJ Precision …, 2024 - nature.com
Malignant pleural effusion (MPE) is a common occurrence in advanced cancer and is often
linked with a poor prognosis. Eosinophils were reported to involve in the development of …

Modeling immunity in microphysiological systems

BJ Kwee, X Li, XX Nguyen… - Experimental …, 2023 - journals.sagepub.com
There is a need for better predictive models of the human immune system to evaluate safety
and efficacy of immunomodulatory drugs and biologics for successful product development …

'Off the shelf'immunotherapies: Generation and application of pluripotent stem cell‐derived immune cells

C Wang, J Liu, W Li - Cell Proliferation, 2023 - Wiley Online Library
In recent years, great strides have been made toward the development of immune cell‐
based therapies in the treatment of refractory malignancies. Primary T cells and NK cells …