[HTML][HTML] Nanoparticle biodistribution coefficients: A quantitative approach for understanding the tissue distribution of nanoparticles
The objective of this manuscript is to provide quantitative insights into the tissue distribution
of nanoparticles. Published pharmacokinetics of nanoparticles in plasma, tumor and 13 …
of nanoparticles. Published pharmacokinetics of nanoparticles in plasma, tumor and 13 …
Integration of in vitro and in vivo models to predict cellular and tissue dosimetry of nanomaterials using physiologically based pharmacokinetic modeling
Nanomaterials (NMs) have been increasingly used in a number of areas, including
consumer products and nanomedicine. Target tissue dosimetry is important in the evaluation …
consumer products and nanomedicine. Target tissue dosimetry is important in the evaluation …
Current approaches and techniques in physiologically based pharmacokinetic (PBPK) modelling of nanomaterials
There have been efforts to develop physiologically based pharmacokinetic (PBPK) models
for nanomaterials (NMs). Since NMs have quite different kinetic behaviors, the applicability …
for nanomaterials (NMs). Since NMs have quite different kinetic behaviors, the applicability …
Physiologically based pharmacokinetic modeling of nanoparticle biodistribution: a review of existing models, simulation software, and data analysis tools
EO Kutumova, IR Akberdin, IN Kiselev… - International Journal of …, 2022 - mdpi.com
Cancer treatment and pharmaceutical development require targeted treatment and less toxic
therapeutic intervention to achieve real progress against this disease. In this scenario …
therapeutic intervention to achieve real progress against this disease. In this scenario …
Emerging investigator series: perspectives on toxicokinetics of nanoscale plastic debris in organisms
Fragmentation of plastic waste in the environment can lead to the formation of nanoscale
plastic debris (NPD) of size< 1 μm. Although it is reported that NPD can be taken up by …
plastic debris (NPD) of size< 1 μm. Although it is reported that NPD can be taken up by …
Advances in Physiologically Based Pharmacokinetic (PBPK) Modeling of Nanomaterials
O Ozbek, DE Genc, K O. Ulgen - ACS Pharmacology & …, 2024 - ACS Publications
Nanoparticles (NPs) have been widely used to improve the pharmacokinetic properties and
tissue distribution of small molecules such as targeting to a specific tissue of interest …
tissue distribution of small molecules such as targeting to a specific tissue of interest …
A new pharmacokinetic model describing the biodistribution of intravenously and intratumorally administered superparamagnetic iron oxide nanoparticles (SPIONs) in …
Background Superparamagnetic iron oxide nanoparticles (SPIONs) have displayed
multifunctional applications in cancer theranostics following systemic delivery. In an effort to …
multifunctional applications in cancer theranostics following systemic delivery. In an effort to …
The LEAP process: streamlining the development of long-acting products and formulations for infectious diseases
C Flexner, M Siccardi, F Bunglawala… - Clinical Infectious …, 2022 - academic.oup.com
Developing long-acting products and formulations for infectious diseases is a nontrivial
undertaking that is frequently classified as high risk and low reward by the pharmaceutical …
undertaking that is frequently classified as high risk and low reward by the pharmaceutical …
A quantitative systems pharmacology (QSP) platform for preclinical to clinical translation of in-vivo CRISPR-Cas therapy
Background: In-vivo CRISPR Cas genome editing is a complex therapy involving lipid
nanoparticle (LNP), messenger RNA (mRNA), and single guide RNA (sgRNA). This novel …
nanoparticle (LNP), messenger RNA (mRNA), and single guide RNA (sgRNA). This novel …
An assessment of applicability of existing approaches to predicting the bioaccumulation of conventional substances in nanomaterials
The experimental determination of bioaccumulation is challenging, and a number of
approaches have been developed for its prediction. It is important to assess the applicability …
approaches have been developed for its prediction. It is important to assess the applicability …