Aminolevulinic acid (ALA) as a prodrug in photodynamic therapy of cancer

M Wachowska, A Muchowicz, M Firczuk, M Gabrysiak… - Molecules, 2011 - mdpi.com
Aminolevulinic acid (ALA) is an endogenous metabolite normally formed in the mitochondria
from succinyl-CoA and glycine. Conjugation of eight ALA molecules yields protoporphyrin IX …

Aminolevulinic acid (ALA): photodynamic detection and potential therapeutic applications

B Nokes, M Apel, C Jones, G Brown, JE Lang - Journal of surgical research, 2013 - Elsevier
Aminolevulinic acid (ALA) is a heme precursor that may have potential applications for
photodynamic detection and photodynamic therapy–based treatment of solid tumors in a …

Systematic review and meta-analysis of in vitro anti-human cancer experiments investigating the use of 5-aminolevulinic acid (5-ALA) for photodynamic therapy

Y Shinoda, D Kato, R Ando, H Endo, T Takahashi… - Pharmaceuticals, 2021 - mdpi.com
5-Aminolevulinic acid (5-ALA) is an amino acid derivative and a precursor of protoporphyrin
IX (PpIX). The photophysical feature of PpIX is clinically used in photodynamic diagnosis …

[HTML][HTML] Potentiation of novel porphyrin based photodynamic therapy against colon cancer with low dose doxorubicin and elucidating the molecular signalling …

U Chilakamarthi, NS Mahadik, D Koteshwar… - … of Photochemistry and …, 2023 - Elsevier
Photodynamic therapy (PDT) is a promising non-invasive treatment modality for cancer and
can be potentiated by combination with chemotherapy. Here, we combined PDT of novel …

Apoptosis of ovarian cancer cells induced by methylene blue-mediated sonodynamic action

J Xiang, X Xia, Y Jiang, AW Leung, X Wang, J Xu… - Ultrasonics, 2011 - Elsevier
OBJECTIVE: The present study aims to investigate apoptosis of ovarian cancer cells
induced by methylene blue (MB)-mediated sonodynamic therapy (SDT). METHODS: The MB …

Study of the efficacy of 5-ALA mediated photodynamic therapy on human rhabdomyosarcoma cell line (RD)

M Atif, M Fakhar-e-Alam, S Firdous… - Laser Physics …, 2010 - iopscience.iop.org
The aim of this study was to investigate the mechanism of cell death by photodynamic
therapy (PDT) in the Rhabdomyosarcoma (RD) cell line. The present study evaluates the …

An Efficient 5-Aminolevulinic Acid Photodynamic Therapy Treatment for Human Hepatocellular Carcinoma

A Kumar, F Pecquenard, M Baydoun, A Quilbé… - International Journal of …, 2023 - mdpi.com
Photodynamic therapy (PDT) is a two-stage treatment relying on cytotoxicity induced by
photoexcitation of a nontoxic dye, called photosensitizer (PS). Using 5-aminolevulinic acid …

In vitro study of 5-aminolevulinic acid-based photodynamic therapy for apoptosis in human cervical HeLa cell line

M Atif, S Firdous, A Khurshid, L Noreen… - Laser Physics …, 2009 - iopscience.iop.org
aminolevulanic acid (ALA), belonging among the promising second generation of
sensitizers, was evaluated as an inducer of photodamage on HeLa (human cervical …

A study on the photodynamic properties of chlorophyll derivatives using human hepatocellular carcinoma cells

WT Li, HW Tsao, YY Chen, SW Cheng… - … & photobiological sciences, 2007 - Springer
Photodynamic therapy (PDT) is an alternative anticancer treatment in which direct tumor-cell
killing results from selective accumulation of photosensitizers in the tumor sites and …

Recent advances in photodynamic imaging and therapy in hepatobiliary malignancies: clinical and experimental aspects

A Nanashima, M Hiyoshi, N Imamura, K Yano… - Current …, 2021 - mdpi.com
The therapeutic and diagnostic modalities of light are well known, and derivative
photodynamic reactions with photosensitizers (PSs), specific wavelengths of light exposure …