The last 10 years have seen some progress in understanding the etiology of autoimmune
thyroid disease (AITD). The female preponderance can now be explained–at least in part …

Graves' disease is the most frequent cause of hyperthyroidism. Many questions remain
about the choice of diagnostic evaluations and treatment strategy according to clinical …

The HLA region encodes several molecules that play key roles in the immune system.
Strong association between the HLA region and autoimmune disease (AID) has been …

Graves' disease is a common autoimmune disorder characterized by thyroid stimulating
hormone receptor autoantibodies (TRAb) and hyperthyroidism. To investigate the genetic …

Highlights•Narcolepsy is caused by the loss of hypocretin-producing neurons in the
brain.•HLA DQB1* 06: 02 association suggests an autoimmune basis for narcolepsy.• …

The major histocompatibility complex system is the most polymorphic gene cluster of the
mammal genome. In humans, this is a genomic locus known as the human leukocyte …

Genome-wide association studies provide insight into multigenic diseases through the
identification of susceptibility genes and etiological pathways. In addition, the identification …

To fine map association signals of human leukocyte antigen (HLA) variants in the major
histocompatibility complex (MHC) region, we constructed a Japanese population-specific …

Thyroid diseases, including autoimmune thyroid diseases and thyroid cancer, are known to
have high heritability. Family and twin studies have indicated that genetics plays a major …

The ability of the immune system to protect the body from attack by foreign antigens is
essential for human survival. The immune system can, however, start to attack the body's …