Triple-negative breast cancer is a heterogeneous disease and specific therapies have not
been available for a long time. Therefore, conventional chemotherapy is still considered the …

During the past decade, cancer stem cells (CSCs) have been increasingly identified in many
malignancies. Although the origin and plasticity of these cells remain controversial, tumour …

Abstract NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are transmembrane receptors that
transduce juxtacrine signals of the delta‑like canonical Notch ligand (DLL) 1, DLL3, DLL4 …

The antineoplastic, prodifferentiative effects of bromodomain and extra-terminal (BET)
bromodomain (BRD) inhibitors were initially discovered in NUT midline carcinoma (NMC) …

Notch has been implicated in human cancers and is a putative therapeutic target. However,
the regulation of Notch activation in the nucleus remains largely uncharacterized. Therefore …

Notch receptors influence cellular behavior by participating in a seemingly simple signaling
pathway, but outcomes produced by Notch signaling are remarkably varied depending on …

Notch signaling pathway is evolutionarily conserved in mammals, which plays an important
role in cell development and differentiation. In recent years, increasing evidence has shown …

Breast cancer (BC) is a serious worldwide disease that threatens women's health.
Particularly, the morbidity of triple-negative breast cancer (TNBC) is higher than that of other …

Importance Recurrent and/or metastatic head and neck cancer is usually incurable.
Implementation of precision oncology for these patients has been limited by incomplete …

Purpose Adenoid cystic carcinomas (ACCs) represent a heterogeneous group of
chemotherapy refractory tumors, with a subset demonstrating an aggressive phenotype. We …