Chemical biology and medicinal chemistry of RNA methyltransferases

TR Fischer, L Meidner, M Schwickert… - Nucleic Acids …, 2022 - academic.oup.com
RNA methyltransferases (MTases) are ubiquitous enzymes whose hitherto low profile in
medicinal chemistry, contrasts with the surging interest in RNA methylation, the arguably …

Isatin thiazoles as antidiabetic: Synthesis, in vitro enzyme inhibitory activities, kinetics, and in silico studies

M Solangi, Kanwal, KM Khan… - Archiv der …, 2022 - Wiley Online Library
Diabetes mellitus is one of the most prevalent diseases nowadays. Several marketed drugs
are available for the cure and treatment of diabetes, but there is still a dire need of …

Study of antiopisthorchiasis activity of sesquiterpene lactones and their derivatives

SM Adekenov - Fitoterapia, 2019 - Elsevier
Study of antiopisthorchiasis activity of sesquiterpene lactones and their derivatives -
ScienceDirect Skip to main contentSkip to article Elsevier logo Journals & Books Search …

Humans from Wuchereria bancrofti endemic area elicit substantial immune response to proteins of the filarial parasite Brugia malayi and its endosymbiont Wolbachia

R Jha, M Gangwar, D Chahar, A Setty Balakrishnan… - Parasites & vectors, 2017 - Springer
Background In the past, immune responses to several Brugia malayi immunodominant
antigens have been characterized in filaria-infected populations; however, little is known …

Cloning, expression and characterization of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) from Wolbachia endosymbiont of human lymphatic filarial …

M Shahab, M Verma, M Pathak, K Mitra… - PLoS …, 2014 - journals.plos.org
Wolbachia, an endosymbiont of filarial nematode, is considered a promising target for
treatment of lymphatic filariasis. Although functional characterization of the Wolbachia …

AtRsmD Is Required for Chloroplast Development and Chloroplast Function in Arabidopsis thaliana

ZY Wang, WT Qu, T Mei, N Zhang, NY Yang… - Frontiers in Plant …, 2022 - frontiersin.org
AtRsmD was recently demonstrated to be a chloroplast 16S rRNA methyltransferase
(MTase) for the m2G915 modification in Arabidopsis. Here, its function of AtRsmD for …

Immunogenicity and protective efficacy of Recombinase A from Wolbachia endosymbiont of filarial nematode Brugia malayi (wBmRecA)

M Gangwar, R Jha, M Goyal, M Srivastava - Vaccine, 2019 - Elsevier
Lymphatic filariasis causes global morbidity. Wolbachia, an endo-symbiotic intracellular
bacterium of the filarial nematode helps in their growth and development, regulates …

[PDF][PDF] Development of DNMT2 inhibitors for the selective manipulation of the epitranscriptome

T Fischer - 2022 - openscience.ub.uni-mainz.de
The research discipline of epitranscriptomics dealing with ribonucleic acid (RNA)
modifications has gained increased popularity over the last decade. With the discovery of …

Progress in the treatment and control of lymphatic filariasis

S Misra-Bhattacharya, M Shahab - Lymphatic Filariasis: Epidemiology …, 2018 - Springer
Lymphatic filariasis caused by tissue nematodes is a nonfatal public health disease which
causes huge deformities in several tropical and subtropical countries including India leading …

Fighting fire with fire: Computational prediction of microbial targets for bacteriocins

ED Coelho, JP Arrais, JL Oliveira - … IWBBIO 2018, Granada, Spain, April 25 …, 2018 - Springer
Recently, we have witnessed the emergence of bacterial strains resistant to all known
antibacterials. Due to several limitations of existing experimental methods, these events …