Protein phosphorylation is a crucial regulator of protein and cellular function, yet, despite
identifying an enormous number of phosphorylation sites, the role of most is still unclear …

The native chemical ligation reaction (NCL) involves reacting a C-terminal peptide thioester
with an N-terminal cysteinyl peptide to produce a native peptide bond between the two …

The homochirality of biomolecules in nature, such as DNA, RNA, peptides and proteins, has
played a critical role in establishing and sustaining life on Earth. This chiral bias has also …

Membrane‐associated D‐proteins are an important class of synthetic molecules needed for
D‐peptide drug discovery, but their chemical synthesis using canonical ligation methods …

Protein semisynthesis—defined herein as the assembly of a protein from a combination of
synthetic and recombinant fragments—is a burgeoning field of chemical biology that has …

Contemporary chemical protein synthesis has been dramatically advanced over the past few
decades, which has enabled chemists to reach the landscape of synthetic …

Chemical ligation of peptides is increasingly used to generate proteins not readily
accessible by recombinant approaches. However, a robust method to ligate “difficult” …

Solid-phase peptide synthesis (SPPS) is generally the method of choice for the chemical
synthesis of peptides, allowing routine synthesis of virtually any type of peptide sequence …

Limited understanding of human proteoforms with complex posttranslational modifications
and the underlying mechanisms poses a major obstacle to research on human health and …

D‐peptide ligands can be screened for therapeutic potency and enzymatic stability using
synthetic mirror‐image proteins (D‐proteins), but efficient acquisition of these D‐proteins …