Mechanisms of clathrin-mediated endocytosis

M Kaksonen, A Roux - Nature reviews Molecular cell biology, 2018 - nature.com
Clathrin-mediated endocytosis is a key process in vesicular trafficking that transports a wide
range of cargo molecules from the cell surface to the interior. Clathrin-mediated endocytosis …

Endocytosis in the context-dependent regulation of individual and collective cell properties

S Sigismund, L Lanzetti, G Scita… - Nature Reviews Molecular …, 2021 - nature.com
Endocytosis allows cells to transport particles and molecules across the plasma membrane.
In addition, it is involved in the termination of signalling through receptor downmodulation …

SARS-CoV-2 requires acidic pH to infect cells

AJB Kreutzberger, A Sanyal… - Proceedings of the …, 2022 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry starts with
membrane attachment and ends with spike (S) protein–catalyzed membrane fusion …

Deep learning enables cross-modality super-resolution in fluorescence microscopy

H Wang, Y Rivenson, Y Jin, Z Wei, R Gao… - Nature …, 2019 - nature.com
We present deep-learning-enabled super-resolution across different fluorescence
microscopy modalities. This data-driven approach does not require numerical modeling of …

HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation

VG Magupalli, R Negro, Y Tian, AV Hauenstein… - Science, 2020 - science.org
INTRODUCTION Canonical inflammasomes are multicomponent protein complexes that
play key roles in immune surveillance of infections and danger by activating caspase-1 …

Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms

TL Liu, S Upadhyayula, DE Milkie, V Singh, K Wang… - Science, 2018 - science.org
INTRODUCTION Organisms live by means of the complex, dynamic, three-dimensional (3D)
interplay between millions of components, from the molecular to the multicellular. Visualizing …

Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution

R Gao, SM Asano, S Upadhyayula, I Pisarev, DE Milkie… - Science, 2019 - science.org
INTRODUCTION Neural circuits across the brain are composed of structures spanning
seven orders of magnitude in size that are assembled from thousands of distinct protein …

An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion

S Luo, J Zhang, AJB Kreutzberger, A Eaton… - Science …, 2022 - science.org
SARS-CoV-2 Omicron subvariants have generated a worldwide health crisis due to
resistance to most approved SARS-CoV-2 neutralizing antibodies and evasion of …

[HTML][HTML] A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility

SH Sheu, S Upadhyayula, V Dupuy, S Pang, F Deng… - Cell, 2022 - cell.com
Chemical synapses between axons and dendrites mediate neuronal intercellular
communication. Here, we describe a synapse between axons and primary cilia: the axo …

Image processing tools for petabyte-scale light sheet microscopy data

X Ruan, M Mueller, G Liu, F Görlitz, TM Fu, DE Milkie… - Nature …, 2024 - nature.com
Light sheet microscopy is a powerful technique for high-speed three-dimensional imaging of
subcellular dynamics and large biological specimens. However, it often generates datasets …