Abstract Huntington's disease (HD)(OMIM 143100) is caused by an expanded CAG repeat
tract in the HTT gene. The inherited CAG length is known to expand further in somatic and …

There are over 40 autosomal dominant spinocerebellar ataxias (SCAs) now identified. In this
chapter we delineate the phenotypes of SCAs 1-44 and dentatorubral-pallidoluysian atrophy …

Interest in the cerebellum is expanding given evidence of its contributions to cognition and
emotion, and dysfunction in various psychopathologies. However, research into its genetic …

Micronutrient status of parents can affect long term health of their progeny. Around 2 billion
humans are affected by chronic micronutrient deficiency. In this study we use zebrafish as a …

Spinocerebellar ataxias (SCAs) are a heterogenous group of neurodegenerative disorders
which commonly inherited in an autosomal dominant manner. They cause muscle …

Abstract Spinocerebellar ataxia type 12 (SCA12) is a neurogenetic disease, marked with
prominent action tremors in the upper limbs. Neuroimaging techniques like magnetic …

Polyglutamine (polyQ) regions are highly abundant consecutive runs of glutamine residues.
They have been generally studied in relation to the so-called polyQ-associated diseases …

Spinocerebellar ataxia type 10 (SCA10) is characterized by progressive cerebellar
neurodegeneration and, in many patients, epilepsy. This disease mainly occurs in …

Cerebellar ataxias (CAs) represent a group of autosomal dominant and recessive
neurodegenerative disorders affecting cerebellum with or without spinal cord. Overall, CAs …

Background Spinocerebellar ataxia type 12 (SCA12) is a neurodegenerative disease
caused by expansion of a CAG repeat in the PPP2R2B gene. Objective In this study, we …