Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

This brief review of the human Na/H exchanger gene family introduces a new classification
with three subgroups to the SLC9 gene family. Progress in the structure and function of this …

NHE3 is the brush-border (BB) Na+/H+ exchanger of small intestine, colon, and renal
proximal tubule which is involved in large amounts of neutral Na+ absorption. NHE3 is a …

Abstract The Na+/H+-exchanger NHE1 and the monocarboxylate transporters MCT1 and
MCT4 are crucial for intracellular pH regulation, particularly under active metabolism. NHE1 …

The Na+/H+-exchanger 1, NHE1 (SLC9A1) and the electroneutral Na+, HCO3--
cotransporter NBCn1 (SLC4A7) are coexpressed in a wide range of tissues. Under normal …

To control net sodium (Na+) uptake, Arabidopsis plants utilize the plasma membrane (PM)
Na+/H+ antiporter SOS1 to achieve Na+ efflux at the root and Na+ loading into the xylem …

The plant SOS2 family of protein kinases and their interacting activators, the SOS3 family of
calcium-binding proteins, function together in decoding calcium signals elicited by different …

The transmembranal Na+/H+ antiporters transport sodium (or several other monovalent
cations) in exchange for H+ across lipid bilayers in all kingdoms of life. They are critical in …

The epithelial brush border Na/H exchanger NHE3 is active under basal conditions and
functions as part of neutral NaCl absorption in the intestine and renal proximal tubule, where …

The Na+ gradient produced across the cardiac sarcolemma by the ATP-dependent Na+-
pump is a constant source of energy for Na+-dependent transporters. The plasma …