Free radicals and other reactive species (RS) are thought to play an important role in many
human diseases. Establishing their precise role requires the ability to measure them and the …

Oxidative stress, an imbalance toward the pro-oxidant side of the pro-oxidant/antioxidant
homeostasis, occurs in several human diseases. Among these diseases are those in which …

We summarize here results of studies designed to elucidate basic mechanisms of reactive
oxygen (ROS)-mediated oxidation of proteins and free amino acids. These studies have …

The advent of O2 in the atmosphere was among the first major pollution events occurred on
earth. The reaction between ferrous iron, very abundant in the reductive early atmosphere …

Radical-mediated damage to proteins may be initiated by electron leakage, metal-ion-
dependent reactions and autoxidation of lipids and sugars. The consequent protein …

Protein oxidation is involved in regulatory physiological events as well as in damage to
tissues and is thought to play a key role in the pathophysiology of diseases and in the aging …

Cigarette smoke is an aerosol that contains> 4,000 chemicals, including nicotine, carbon
monoxide, acrolein, and oxidant compounds. Exposure to cigarette smoke induces multiple …

In the setting of liver cirrhosis (LC), profound hemostatic changes occur, which affect primary
hemostasis, coagulation, and fibrinolysis. They involve prohemorrhagic and prothrombotic …

Protein oxidation is defined here as the covalent modification of a protein induced either
directly by reactive oxygen species or indirectly by reaction with secondary by-products of …

The oxidative modification of proteins by reactive species is implicated in the etiology or
progression of a panoply of disorders and diseases. The level of these modified molecules …