Triple-negative breast cancer: current understanding and future therapeutic breakthrough targeting cancer stemness
KL Lee, YC Kuo, YS Ho, YH Huang - Cancers, 2019 - mdpi.com
Triple-negative breast cancer (TNBC) is cancer that tested as negative for estrogen
receptors (ER), progesterone receptors (PR), and excess human epidermal growth factor …
receptors (ER), progesterone receptors (PR), and excess human epidermal growth factor …
Neuronal and extraneuronal nicotinic acetylcholine receptors
Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cysloop
ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other …
ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other …
Thermostability, tunability, and tenacity of RNA as rubbery anionic polymeric materials in nanotechnology and nanomedicine—specific cancer targeting with …
RNA nanotechnology is the bottom-up self-assembly of nanometer-scale architectures,
resembling LEGOs, composed mainly of RNA. The ideal building material should be (1) …
resembling LEGOs, composed mainly of RNA. The ideal building material should be (1) …
[HTML][HTML] Nitrosamines crisis in pharmaceuticals− Insights on toxicological implications, root causes and risk assessment: A systematic review
HPR Vikram, TP Kumar, G Kumar, NM Beeraka… - Journal of …, 2024 - Elsevier
The presence of N-nitroso compounds, particularly N-nitrosamines, in pharmaceutical
products has raised global safety concerns due to their significant genotoxic and mutagenic …
products has raised global safety concerns due to their significant genotoxic and mutagenic …
[HTML][HTML] 1B50-1, a mAb raised against recurrent tumor cells, targets liver tumor-initiating cells by binding to the calcium channel α2δ1 subunit
W Zhao, L Wang, H Han, K Jin, N Lin, T Guo, Y Chen… - Cancer cell, 2013 - cell.com
The identification and targeted therapy of cells involved in hepatocellular carcinoma (HCC)
recurrence remain challenging. Here, we generated a monoclonal antibody against …
recurrence remain challenging. Here, we generated a monoclonal antibody against …
[HTML][HTML] The apple polyphenol phloretin inhibits breast cancer cell migration and proliferation via inhibition of signals by type 2 glucose transporter
KH Wu, CT Ho, ZF Chen, LC Chen… - journal of food and drug …, 2018 - Elsevier
Human triple-negative breast cancer (TNBC) is the most aggressive and poorly understood
subclass of breast cancer. Glucose transporters (GLUTs) are required for glucose uptake in …
subclass of breast cancer. Glucose transporters (GLUTs) are required for glucose uptake in …
Membrane protein-regulated networks across human cancers
Alterations in membrane proteins (MPs) and their regulated pathways have been
established as cancer hallmarks and extensively targeted in clinical applications. However …
established as cancer hallmarks and extensively targeted in clinical applications. However …
Nicotinic acetylcholine receptors: Conventional and unconventional ligands and signaling
RL Papke, JM Lindstrom - Neuropharmacology, 2020 - Elsevier
Postsynaptic nAChRs in the peripheral nervous system are critical for neuromuscular and
autonomic neurotransmission. Pre-and peri-synaptic nAChRs in the brain modulate …
autonomic neurotransmission. Pre-and peri-synaptic nAChRs in the brain modulate …
Acetylcholine receptors: Key players in cancer development
J Chen, IWY Cheuk, VY Shin, A Kwong - Surgical oncology, 2019 - Elsevier
Acetylcholine (ACh) was first identified as a classic neuromodulator and transmit signals
through two subgroups of receptors, namely muscarinic receptors (mAChRs) and nicotinic …
through two subgroups of receptors, namely muscarinic receptors (mAChRs) and nicotinic …
Nicotine: specific role in angiogenesis, proliferation and apoptosis
A Cardinale, C Nastrucci, A Cesario… - Critical reviews in …, 2012 - Taylor & Francis
Nowadays, tobacco smoking is the cause of~ 5–6 million deaths per year, counting 31% and
6% of all cancer deaths (affecting 18 different organs) in middle-aged men and women …
6% of all cancer deaths (affecting 18 different organs) in middle-aged men and women …