The role of microRNAs in epigenetic regulation of signaling pathways in neurological pathologies

PP Tregub, I Ibrahimli, AS Averchuk… - International journal of …, 2023 - mdpi.com
In recent times, there has been a significant increase in researchers' interest in the functions
of microRNAs and the role of these molecules in the pathogenesis of many multifactorial …

Tanshinone IIA against cerebral ischemic stroke and ischemia-reperfusion injury: a review of the current documents

R Arefnezhad, A Nejabat, F Behjati… - Mini Reviews in …, 2024 - benthamdirect.com
Stroke is a well-known neurological disorder that carries significant morbidity and mortality
rates worldwide. Cerebral Ischemic Stroke (CIS), the most common subtype of stroke, occurs …

Exacerbated ischemic brain damage in type 2 diabetes via methylglyoxal-mediated miR-148a-3p decline

Z Yang, C Huang, W Huang, C Yan, X Wen, D Hu… - BMC medicine, 2024 - Springer
Background Although microvascular dysfunction is a widespread phenomenon in type 2
diabetes (T2D) and is recognized as a main cause of T2D-aggravated ischemic stroke …

Extracellular vesicles derived from endothelial progenitor cells modified by Houshiheisan promote angiogenesis and attenuate cerebral ischemic injury via miR-126 …

Y Zhang, Q Yang, H Cheng, Y Zhang, Y Xie… - Scientific Reports, 2024 - nature.com
Angiogenesis following cerebral ischemia is crucial for restoring blood supply to the
ischemic region. Extracellular vesicles (EVs) derived from endothelial progenitor cells …

Exosomes derived from endothelial progenitor cells ameliorate LPS-induced brain microvascular endothelial cells injury by delivering miR-126a-5p

H Zhang, C Lu, L Wu, J Li, M Huang, X Tao, Y Wu… - Scientific Reports, 2024 - nature.com
Endothelial progenitor cells (EPCs) play a crucial role in maintaining vascular health and
aiding in the repair of damaged blood vessels. However, the specific impact of EPCs …

Hydrogen Sulfide Protects against Rat Ischemic Brain Injury by Promoting RhoA Phosphorylation at Serine 188

Y Chen, S Chen, M Wu, F Chen, Q Guan, S Zhang… - ACS …, 2024 - ACS Publications
The protective role of hydrogen sulfide against cerebral ischemia-reperfusion injury involves
the inhibition of the RhoA-/Rho-associated coiled-coil kinase (ROCK) pathway. However …

[PDF][PDF] In Vivo Experimental Models of Cerebral Ischemia: Analysis, Translational Potential and Clinical Relevance

L Radenovic - Cardiol. Res. Cardiovasc. Med, 2024 - researchgate.net
Despite all current efforts in the field of cerebrovascular disease prevention, stroke remains
the leading cause of disability and death worldwide. Animal models are essential tools in …

Can miRNAs in MSCs-EVs Offer a Potential Treatment for Hypoxic-ischemic Encephalopathy?

H Al-Ward, W Chen, W Gao, C Zhang, X Yang… - Stem Cell Reviews and …, 2024 - Springer
Neonatal hypoxic-ischemic encephalopathy (HIE) is a critical condition resulting from
impaired oxygen and blood flow to the brain during birth, leading to neuroinflammation …

MicroRNA-24 therapeutic potentials in infarction, stroke, and diabetic complications

SH Rastegar-Moghaddam, M Bigham… - Molecular Biology …, 2024 - Springer
The prevalence of cardiovascular events, stroke, and diabetes worldwide underscores the
urgent need for effective and minimally invasive treatments. With nearly 20 million annual …

Therapeutic gene delivery by mesenchymal stem cell for brain ischemia damage: Focus on molecular mechanisms in ischemic stroke

RO Saleh, AA Majeed, R Margiana… - Cell Biochemistry …, 2024 - Wiley Online Library
Cerebral ischemic damage is prevalent and the second highest cause of death globally
across patient populations; it is as a substantial reason of morbidity and mortality …