The human virome: assembly, composition and host interactions

G Liang, FD Bushman - Nature Reviews Microbiology, 2021 - nature.com
The human body hosts vast microbial communities, termed the microbiome. Less well
known is the fact that the human body also hosts vast numbers of different viruses …

Contamination in low microbial biomass microbiome studies: issues and recommendations

R Eisenhofer, JJ Minich, C Marotz, A Cooper… - Trends in …, 2019 - cell.com
Next-generation sequencing approaches in microbiome research have allowed surveys of
microbial communities, their genomes, and their functions with higher sensitivity than ever …

The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota

C Milani, S Duranti, F Bottacini, E Casey… - Microbiology and …, 2017 - Am Soc Microbiol
The human gut microbiota is engaged in multiple interactions affecting host health during
the host's entire life span. Microbes colonize the neonatal gut immediately following birth …

A critical assessment of the “sterile womb” and “in utero colonization” hypotheses: implications for research on the pioneer infant microbiome

ME Perez-Muñoz, MC Arrieta, AE Ramer-Tait, J Walter - microbiome, 2017 - Springer
After more than a century of active research, the notion that the human fetal environment is
sterile and that the neonate's microbiome is acquired during and after birth was an accepted …

Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery

DM Chu, J Ma, AL Prince, KM Antony, MD Seferovic… - Nature medicine, 2017 - nature.com
Human microbial communities are characterized by their taxonomic, metagenomic and
metabolic diversity, which varies by distinct body sites and influences human physiology …

Human placenta has no microbiome but can contain potential pathogens

MC De Goffau, S Lager, U Sovio, F Gaccioli, E Cook… - Nature, 2019 - nature.com
We sought to determine whether pre-eclampsia, spontaneous preterm birth or the delivery of
infants who are small for gestational age were associated with the presence of bacterial …

Rebuilding the gut microbiota ecosystem

A Gagliardi, V Totino, F Cacciotti, V Iebba… - International journal of …, 2018 - mdpi.com
A microbial ecosystem in which bacteria no longer live in a mutualistic association is called
dysbiotic. Gut microbiota dysbiosis is a condition related with the pathogenesis of intestinal …

Maternal microbiota, early life colonization and breast milk drive immune development in the newborn

C Kalbermatter, N Fernandez Trigo… - Frontiers in …, 2021 - frontiersin.org
The innate immune system is the oldest protection strategy that is conserved across all
organisms. Although having an unspecific action, it is the first and fastest defense …

Optimizing methods and dodging pitfalls in microbiome research

D Kim, CE Hofstaedter, C Zhao, L Mattei, C Tanes… - Microbiome, 2017 - Springer
Research on the human microbiome has yielded numerous insights into health and disease,
but also has resulted in a wealth of experimental artifacts. Here, we present suggestions for …

Fetal meconium does not have a detectable microbiota before birth

KM Kennedy, MJ Gerlach, T Adam, MM Heimesaat… - Nature …, 2021 - nature.com
Microbial colonization of the human intestine impacts host metabolism and immunity;
however, exactly when colonization occurs is unclear. Although many studies have reported …