Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond
Amongst heterocyclic compounds, quinoline and its derivatives are advantaged scaffolds
that appear as a significant assembly motif for developing new drug entities. Aminoquinoline …
that appear as a significant assembly motif for developing new drug entities. Aminoquinoline …
Triazole hybrid compounds: A new frontier in malaria treatment
Reviewing the advancements in malaria treatment, the emergence of triazole hybrid
compounds stands out as a groundbreaking development. Combining the advantages of …
compounds stands out as a groundbreaking development. Combining the advantages of …
Recent developments in antimalarial activities of 4-aminoquinoline derivatives
Malaria is the fifth most lethal parasitic infection in the world. Antimalarial medications have
played a crucial role in preventing and eradicating malaria. Numerous heterocyclic moieties …
played a crucial role in preventing and eradicating malaria. Numerous heterocyclic moieties …
Recent developments in the synthesis of hybrid antimalarial drug discovery
In this 21 st century, Malaria remains a global burden and causes massive economic trouble
to disease-endemic nations. The control and eradication of malaria is a major challenge that …
to disease-endemic nations. The control and eradication of malaria is a major challenge that …
Activation of endoplasmic reticulum stress by harmine suppresses the growth of esophageal squamous cell carcinoma
R Fan, S Wang, Y Wu, Y Feng, M Gao… - Phytotherapy …, 2023 - Wiley Online Library
The worldwide overall 5‐year survival rate of esophageal squamous cell carcinoma (ESCC)
patients is less than 20%, and novel therapeutic strategies for these patients are urgently …
patients is less than 20%, and novel therapeutic strategies for these patients are urgently …
MalariaFlow: A comprehensive deep learning platform for multistage phenotypic antimalarial drug discovery
Malaria remains a significant global health challenge due to the growing drug resistance of
Plasmodium parasites and the failure to block transmission within human host. While …
Plasmodium parasites and the failure to block transmission within human host. While …
Harmicens, novel harmine and ferrocene hybrids: design, synthesis and biological activity
Cancer and malaria are both global health threats. Due to the increase in the resistance to
the known drugs, research on new active substances is a priority. Here, we present the …
the known drugs, research on new active substances is a priority. Here, we present the …
Development of diphenylmethylpiperazine hybrids of chloroquinoline and triazolopyrimidine using Petasis reaction as new cysteine proteases inhibitors for malaria …
Malaria is a widespread infectious disease, causing nearly 247 million cases in 2021. The
absence of a broadly effective vaccine and rapidly decreasing effectiveness of most of the …
absence of a broadly effective vaccine and rapidly decreasing effectiveness of most of the …
Design and synthesis of pyrano [2, 3-c] pyrazole-4-aminoquinoline hybrids as effective antimalarial compounds
R Lekkala, YH Ng, SR Feroz, NAZB Norazmi… - European Journal of …, 2024 - Elsevier
In this work, a series of nineteen novel pyrano [2, 3-c] pyrazole-4-aminoquinoline hybrids
were synthesized as potent antimalarial agents by covalently linking the scaffolds of 4 …
were synthesized as potent antimalarial agents by covalently linking the scaffolds of 4 …
Synthesis and biological evaluation of new quinoline and anthranilic acid derivatives as potential quorum sensing inhibitors
Inhibiting quorum sensing (QS), a central communication system, is a promising strategy to
combat bacterial pathogens without antibiotics. Here, we designed novel hybrid compounds …
combat bacterial pathogens without antibiotics. Here, we designed novel hybrid compounds …