Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine

MS de Almeida, E Susnik, B Drasler… - Chemical society …, 2021 - pubs.rsc.org
Nanoparticles (NPs) have attracted considerable attention in various fields, such as
cosmetics, the food industry, material design, and nanomedicine. In particular, the fast …

Nanoparticle uptake: the phagocyte problem

HH Gustafson, D Holt-Casper, DW Grainger… - Nano today, 2015 - Elsevier
Phagocytes are key cellular participants determining important aspects of host exposure to
nanomaterials, initiating clearance, biodistribution and the tenuous balance between host …

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

E Fröhlich - International journal of nanomedicine, 2012 - Taylor & Francis
Many types of nanoparticles (NPs) are tested for use in medical products, particularly in
imaging and gene and drug delivery. For these applications, cellular uptake is usually a …

Chemical basis of interactions between engineered nanoparticles and biological systems

Q Mu, G Jiang, L Chen, H Zhou, D Fourches… - Chemical …, 2014 - ACS Publications
As defined by the European Commission, a nanomaterial is a natural, an incidental, or a
manufactured material containing particles in an unbound state or as an aggregate or …

Intracellular delivery of nanomaterials: how to catch endosomal escape in the act

TF Martens, K Remaut, J Demeester, SC De Smedt… - Nano Today, 2014 - Elsevier
Successful cytosolic delivery of nanomaterials is becoming more and more important, given
the increase in intracellular applications of quantum dots, gold nanoparticles, liposomal drug …

Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress

H Peng, J Yang, G Li, Q You, W Han, T Li, D Gao, X Xie… - Cell research, 2017 - nature.com
Alterations in cellular ubiquitin (Ub) homeostasis, known as Ub stress, feature and affect
cellular responses in multiple conditions, yet the underlying mechanisms are incompletely …

Endocytosis of gene delivery vectors: from clathrin-dependent to lipid raft-mediated endocytosis

A El-Sayed, H Harashima - Molecular Therapy, 2013 - cell.com
The ideal nonviral vector delivers its nucleic acid cargo to a specific intracellular target.
Vectors enter cells mainly through endocytosis and are distributed to various intracellular …

Rapid internalization of nanoparticles by human cells at the single particle level

CJ Richards, TCQ Burgers, R Vlijm, WH Roos… - ACS …, 2023 - ACS Publications
Nanoparticle uptake by cells has been studied for applications both in nanomedicine and in
nanosafety. While the majority of studies have focused on the biological mechanisms …

Particle tracking in drug and gene delivery research: State-of-the-art applications and methods

BS Schuster, LM Ensign, DB Allan, JS Suk… - Advanced drug delivery …, 2015 - Elsevier
Particle tracking is a powerful microscopy technique to quantify the motion of individual
particles at high spatial and temporal resolution in complex fluids and biological specimens …

Near-infrared phototheranostic iron pyrite nanocrystals simultaneously induce dual cell death pathways via enhanced fenton reactions in triple-negative breast cancer

C Zhao, Z Liu, CC Chang, YC Chen, Q Zhang… - ACS …, 2023 - ACS Publications
Triple-negative breast cancer (TNBC) is considered more aggressive with a poorer
prognosis than other breast cancer subtypes. Through systemic bioinformatic analyses, we …