Recent advances in the design and discovery of synthetic tyrosinase inhibitors
J Li, L Feng, L Liu, F Wang, L Ouyang, L Zhang… - European Journal of …, 2021 - Elsevier
Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting
catalytic step in the melanin biosynthesis and enzymatic browning. As a promising target …
catalytic step in the melanin biosynthesis and enzymatic browning. As a promising target …
Medicinal prospects of targeting tyrosinase: A feature review
Y Wang, B Xiong, S Xing, Y Chen… - Current Medicinal …, 2023 - ingentaconnect.com
Tyrosinase is a bifunctional polyphenol oxidase (PPO), catalyzing two oxidative reactions:
monophenols to o-quinones (monophenolase activity) and o-diphenols to oquinones …
monophenols to o-quinones (monophenolase activity) and o-diphenols to oquinones …
The natural-based optimization of kojic acid conjugated to different thio-quinazolinones as potential anti-melanogenesis agents with tyrosinase inhibitory activity
Melanin pigment and melanogenesis are a two-edged sword. Melanin has a radioprotection
role while melanogenesis has undesirable effects. Targeting the melanogenesis pathway, a …
role while melanogenesis has undesirable effects. Targeting the melanogenesis pathway, a …
Anti-melanogenesis and anti-tyrosinase properties of aryl-substituted acetamides of phenoxy methyl triazole conjugated with thiosemicarbazide: Design, synthesis …
H Hosseinpoor, SM Farid, A Iraji, MS Asgari… - Bioorganic …, 2021 - Elsevier
A series of aryl phenoxy methyl triazole conjugated with thiosemicarbazides were designed,
synthesized, and evaluated for their tyrosinase inhibitory activities in the presence of l-dopa …
synthesized, and evaluated for their tyrosinase inhibitory activities in the presence of l-dopa …
Thioquinoline derivatives conjugated to thiosemicarbazide as potent tyrosinase inhibitors with anti-melanogenesis properties
In the present study, a series of aryl-substituted thioqunoline conjugated to
thiosemicarbazide were rationally designed and synthesized. The formation of target …
thiosemicarbazide were rationally designed and synthesized. The formation of target …
Evaluating the effects of disubstituted 3-hydroxy-1H-pyrrol-2 (5H)-one analog as novel tyrosinase inhibitors
In the present study, a series of 3-hydroxy-1H-pyrrol-2 (5H)-one derivative were rationally
designed and synthesized. The structure of targeted compounds was confirmed by IR, 1 H …
designed and synthesized. The structure of targeted compounds was confirmed by IR, 1 H …
Design, synthesis, and biological evaluation of symmetrical azine derivatives as novel tyrosinase inhibitors
A series of symmetrical azine derivatives containing different substituted benzyl moieties
were designed, synthesized, and evaluated for their inhibitory activity against tyrosinase …
were designed, synthesized, and evaluated for their inhibitory activity against tyrosinase …
Design and synthesis of multi-target directed 1, 2, 3-triazole-dimethylaminoacryloyl-chromenone derivatives with potential use in Alzheimer's disease
H Karimi Askarani, A Iraji, A Rastegari… - BMC chemistry, 2020 - Springer
To discover multifunctional agents for the treatment of Alzheimer's disease (AD), a new
series of 1, 2, 3-triazole-chromenone derivatives were designed and synthesized based on …
series of 1, 2, 3-triazole-chromenone derivatives were designed and synthesized based on …
Antioxidant activity, anti-tyrosinase activity, molecular docking studies, and molecular dynamic simulation of active compounds found in nipa palm vinegar
Tyrosinase is a key enzyme in melanogenesis and its inhibitors have become increasingly
because of their potential activity as hypopigmenting agents which have less side effects …
because of their potential activity as hypopigmenting agents which have less side effects …
Design, synthesis, spectroscopic characterization, in vitro tyrosinase inhibition, antioxidant evaluation, in silico and kinetic studies of substituted indole …
A Iraji, N Sheikhi, M Attarroshan, GRS Ardani… - Bioorganic …, 2022 - Elsevier
In the current study, twenty-five indole-carbohydrazide derivatives linked to different aryl
substitutions were rationally designed and synthesized. The structures of all derivatives …
substitutions were rationally designed and synthesized. The structures of all derivatives …