Different studies corroborate a role for ceramide synthases and their downstream products,
ceramides, in modulation of apoptosis and autophagy in the context of cancer. These …

Lung cancer is the leading cause of cancer deaths worldwide. Most of lung cancer cases are
classified as non-small cell lung cancers (NSCLC). EGFR has become an important …

Lung cancer, renowned for its fast progression and metastatic potency, is rising to become a
leading cause of death globally. It has been long observed that lung cancer is particularly …

Simple Summary Colorectal cancer (CRC) is the third-most diagnosed cancer and the
second-leading cause of cancer-related deaths worldwide. Limitations in early and accurate …

Enzymes related to sphingolipids metabolism has been suggested as altered in oral
squamous cell carcinoma (OSCC). However, clinical relevance of diverse sphingolipids in …

Abstract Introduction Ceramide synthases (CERSes) are also known longevity assurance
(LASS) genes. CERSes play important roles in the regulation of cancer progression. The …

Sphingolipids are important bioactive lipids that not only play an important role in
maintaining the barrier function and fluidity of cell membranes but also regulate multiple …

Purpose Limited treatment options and lack of treatment sensitivity biomarkers make the
clinical management of triple-negative breast cancer (TNBC) challenging. Ceramide …

Simple Summary Abnormal expression of miRNA is often observed in cancer. MiR-101 is
closely associated with tumor initiation and progression. In this review, we summarized new …

Simple Summary CERS6 is known to be associated with metastasis and poor prognosis in
non-small cell lung cancer (NSCLC) patients because of C16 ceramide production, though …