Pharmacological properties of chalcones: a review of preclinical including molecular mechanisms and clinical evidence
Chalcones are among the leading bioactive flavonoids with a therapeutic potential
implicated to an array of bioactivities investigated by a series of preclinical and clinical …
implicated to an array of bioactivities investigated by a series of preclinical and clinical …
Chalcone: a promising bioactive scaffold in medicinal chemistry
Chalcones are a class of privileged scaffolds with high medicinal significance due to the
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …
Anti-diabetic drugs recent approaches and advancements
J Dowarah, VP Singh - Bioorganic & medicinal chemistry, 2020 - Elsevier
Diabetes is one of the major diseases worldwide and is the third leading cause of death in
the United States. Anti-diabetic drugs are used in the treatment of diabetes mellitus to control …
the United States. Anti-diabetic drugs are used in the treatment of diabetes mellitus to control …
[HTML][HTML] Bis-chalcones: A review of synthetic methodologies and anti-inflammatory effects
Chalcones are bioactive molecules of natural and synthetic sources, whose
physicochemical properties, reactivity, and biological activities are well-known among the …
physicochemical properties, reactivity, and biological activities are well-known among the …
A facile approach synthesis of benzoylaryl benzimidazole as potential α-amylase and α-glucosidase inhibitor with antioxidant activity
LM Aroua, HR Almuhaylan, FM Alminderej… - Bioorganic …, 2021 - Elsevier
Synthetic routes to a series of benzoylarylbenzimidazol 3a-h have been derived from 3, 4-
diaminobenzophenone and an appropriate arylaldehyde in the presence of ammonium …
diaminobenzophenone and an appropriate arylaldehyde in the presence of ammonium …
[HTML][HTML] Ultrasound-assisted synthesis of novel chalcone, heterochalcone and bis-chalcone derivatives and the evaluation of their antioxidant properties and as …
E Polo, N Ibarra-Arellano, L Prent-Peñaloza… - Bioorganic …, 2019 - Elsevier
The chalcone and bis-chalcone derivatives have been synthesized under sonication
conditions via Claisen-Schmidt condensation with KOH in ethanol at room temperature (20 …
conditions via Claisen-Schmidt condensation with KOH in ethanol at room temperature (20 …
Chalcone derivatives with a high potential as multifunctional antioxidant neuroprotectors
A Pérez-González, R Castañeda-Arriaga… - ACS …, 2022 - ACS Publications
A systematic, rational search for chalcone derivatives with multifunctional behavior has been
carried out, with the support of a computer-assisted protocol (CADMA-Chem). A total of 568 …
carried out, with the support of a computer-assisted protocol (CADMA-Chem). A total of 568 …
A systematic review on anti-diabetic properties of chalcones
The use of anti-diabetic drugs has been increasing worldwide and the evolution of
therapeutics has been enormous. Still, the currently available anti-diabetic drugs do not …
therapeutics has been enormous. Still, the currently available anti-diabetic drugs do not …
Synthesis of new indazole based dual inhibitors of α-glucosidase and α-amylase enzymes, their in vitro, in silico and kinetics studies
The current study describes the discovery of novel inhibitors of α-glucosidase and α-
amylase enzymes. For that purpose, new hybrid analogs of N-hydrazinecarbothioamide …
amylase enzymes. For that purpose, new hybrid analogs of N-hydrazinecarbothioamide …
Synthesis of azachalcones, their α-amylase, α-glucosidase inhibitory activities, kinetics, and molecular docking studies
Diabetes being a chronic metabolic disorder have attracted the attention of medicinal
chemists and biologists. The introduction of new and potential drug candidates for the cure …
chemists and biologists. The introduction of new and potential drug candidates for the cure …