Liver fibrosis is an advanced liver disease condition, which could progress to cirrhosis and
hepatocellular carcinoma. To date, there is no direct approved antifibrotic therapy, and …

Liver regeneration is a complex process involving the crosstalk of multiple cell types,
including hepatocytes, hepatic stellate cells, endothelial cells and inflammatory cells. The …

Modern medicine has been waging a war on cancer for nearly a century with no tangible
end in sight. Cancer treatments have significantly progressed, but the need to increase …

Punica granatum L (pomegranate) is one of the Mediterranean medicinal plants that has
been used for generations in treating ulcers, diarrhea, and male infertility. Increasing …

Fibrosis refers to the excessive deposition of extracellular matrix components in the
processes of wound repair or tissue regeneration after tissue damage. Fibrosis occurs in …

Liver fibrosis is a substantial risk factor for the development and progression of liver cancer,
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …

Inflammaging, characterized by an increase in low‐grade chronic inflammation with age, is a
hallmark of aging and is strongly associated with various age‐related diseases, including …

Mesenchymal stromal/stem cells (MSCs) are multipotent adult stem cells that support
homeostasis during tissue regeneration. In the last decade, cell therapies based on the use …

Increasing evidence suggests that metabolites produced by the gut microbiota play a crucial
role in host–microbe interactions. Dietary tryptophan ingested by the host enters the gut …

Cancer associated fibroblasts (CAF) and the extracellular matrix (ECM) produced by them
have been recognized as key players in cancer biology and emerged as important targets …