The specific role of the chloride anion (Cl−) as a signalling effector or second messenger
has been increasingly recognized in recent years. It could represent a key factor in the …

Chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) are lethal pulmonary
diseases. Cigarette consumption is the main cause for development of COPD, while CF is …

The impairment of the cystic fibrosis transmembrane conductance regulator (CFTR) activity
induces intracellular chloride (Cl–) accumulation. The anion Cl–, acting as a second …

Cystic fibrosis (CF) is a frequent and lethal autosomal recessive disease. It results from
different possible mutations in the CFTR gene, which encodes the CFTR chloride channel …

Background Cystic fibrosis transmembrane conductance regulator (CFTR) was recently
found in the enteric nervous system, where its role is unclear. We aimed to identify which …

Cystic fibrosis (CF) is caused by mutations in the CFTR gene, which encodes a cAMP‐
regulated chloride channel. Several cellular functions are altered in CF cells. However, it is …

In the airway, Cl-is the most abundant anion and is critically involved in transepithelial
transport. The correlation of the abnormal expression and activation of chloride channels …

Cystic Fibrosis (CF) is a disease caused by mutations in the cystic fibrosis transmembrane
conductance regulator (CFTR) gene. Previously, we found several genes showing a …

Abstract In Cystic Fibrosis (CF), the impairment of the CFTR channel activity leads to a
variety of alterations, including differential gene expression. However, the CFTR signaling …

Fluorescence spectroscopy has, over the last two decades, been frequently used for studies
of biological cells and their molecular components. In combination with molecular biological …