Toxin-antitoxin systems in bacterial pathogenesis

S Sonika, S Singh, S Mishra, S Verma - Heliyon, 2023 - cell.com
Toxin-Antitoxin (TA) systems are abundant in prokaryotes and play an important role in
various biological processes such as plasmid maintenance, phage inhibition, stress …

Advances in bacterial pathways for the biosynthesis of ubiquinone

SS Abby, K Kazemzadeh, C Vragniau, L Pelosi… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Ubiquinone is an important component of the electron transfer chains in proteobacteria and
eukaryotes. The biosynthesis of ubiquinone requires multiple steps, most of which are …

Systematic exploration of Escherichia coli phage–host interactions with the BASEL phage collection

E Maffei, A Shaidullina, M Burkolter, Y Heyer… - PLoS …, 2021 - journals.plos.org
Bacteriophages, the viruses infecting bacteria, hold great potential for the treatment of
multidrug-resistant bacterial infections and other applications due to their unparalleled …

Coenzyme Q biosynthesis: an update on the origins of the benzenoid ring and discovery of new ring precursors

L Fernández-del-Río, CF Clarke - Metabolites, 2021 - mdpi.com
Coenzyme Q (ubiquinone or CoQ) is a conserved polyprenylated lipid essential for
mitochondrial respiration. CoQ is composed of a redox-active benzoquinone ring and a long …

A quantitative survey of bacterial persistence in the presence of antibiotics: towards antipersister antimicrobial discovery

JE Salcedo-Sora, DB Kell - Antibiotics, 2020 - mdpi.com
Background: Bacterial persistence to antibiotics relates to the phenotypic ability to survive
lethal concentrations of otherwise bactericidal antibiotics. The quantitative nature of the time …

The zoonotic pathogen Wohlfahrtiimonas chitiniclastica – current findings from a clinical and genomic perspective

A Kopf, B Bunk, T Riedel, P Schröttner - BMC microbiology, 2024 - Springer
The zoonotic pathogen Wohlfahrtiimonas chitiniclastica can cause several diseases in
humans, including sepsis and bacteremia. Although the pathogenesis is not fully …

Bacterial survivors: Evaluating the mechanisms of antibiotic persistence

X Shi, A Zarkan - Microbiology, 2022 - microbiologyresearch.org
Bacteria withstand antibiotic onslaughts by employing a variety of strategies, one of which is
persistence. Persistence occurs in a bacterial population where a subpopulation of cells …

Genome Mining Shows Ubiquitous Presence and Extensive Diversity of Toxin-Antitoxin Systems in Pseudomonas syringae

PP Kandel, M Naumova, C Fautt, RR Patel… - Frontiers in …, 2022 - frontiersin.org
Bacterial toxin-antitoxin (TA) systems consist of two or more adjacent genes, encoding a
toxin and an antitoxin. TA systems are implicated in evolutionary and physiological functions …

Tobramycin-resistant small colony variant mutant of Salmonella enterica serovar Typhimurium shows collateral sensitivity to nitrofurantoin

CZ Wang, YJ Zhang, YF Chu, LG Zhong, JP Xu… - Virulence, 2024 - Taylor & Francis
The increasing antibiotic resistance poses a significant global health challenge, threatening
our ability to combat infectious diseases. The phenomenon of collateral sensitivity, whereby …

Comparative Genomic Analysis of the Human Pathogen Wohlfahrtiimonas Chitiniclastica Provides Insight Into the Identification of Antimicrobial Resistance …

A Kopf, B Bunk, SM Coldewey, F Gunzer… - Frontiers in Cellular …, 2022 - frontiersin.org
Recent studies suggest that Wohlfahrtiimonas chitiniclastica may be the cause of several
diseases in humans including sepsis and bacteremia making the bacterium as a previously …