Potential and therapeutic efficacy of cell-based therapy using mesenchymal stem cells for acute/chronic kidney disease

CW Yun, SH Lee - International journal of molecular sciences, 2019 - mdpi.com
Kidney disease can be either acute kidney injury (AKI) or chronic kidney disease (CKD) and
it can lead to the development of functional organ failure. Mesenchymal stem cells (MSCs) …

[HTML][HTML] Mesenchymal stem cell treatment for autoimmune diseases: a critical review

FE Figueroa, F Carrión, S Villanueva, M Khoury - Biological research, 2012 - SciELO Chile
Mesenchymal stem cells (MSCs) are now known to display not only stem cell multipotency,
but also robust antiinflammatory and regenerative properties. After widespread in-vitro and …

Umbilical cord mesenchymal stem cells derived extracellular vesicles can safely ameliorate the progression of chronic kidney diseases

W Nassar, M El-Ansary, D Sabry, MA Mostafa… - Biomaterials …, 2016 - spj.science.org
Background Bio-products from stem/progenitor cells, such as extracellular vesicles, are
likely a new promising approach for reprogramming resident cells in both acute and chronic …

Bone marrow-derived mesenchymal stem cells repaired but did not prevent gentamicin-induced acute kidney injury through paracrine effects in rats

LA Reis, FT Borges, MJ Simoes, AA Borges… - 2012 - journals.plos.org
This study evaluated the effects of bone marrow-derived mesenchymal stem cells (BMSCs)
or their conditioned medium (CM) on the repair and prevention of Acute Kidney Injury (AKI) …

Human embryonic mesenchymal stem cell-derived conditioned medium rescues kidney function in rats with established chronic kidney disease

A van Koppen, JA Joles, BWM van Balkom, SK Lim… - PloS one, 2012 - journals.plos.org
Chronic kidney disease (CKD) is a major health care problem, affecting more than 35% of
the elderly population worldwide. New interventions to slow or prevent disease progression …

Safety and efficacy of intravenous infusion of allogeneic cryopreserved mesenchymal stem cells for treatment of chronic kidney disease in cats: results of three …

JM Quimby, TL Webb, LM Habenicht… - Stem cell research & …, 2013 - Springer
Introduction Administration of mesenchymal stem cells (MSCs) has been shown to improve
renal function in rodent models of chronic kidney disease (CKD), in part by reducing …

Early intervention with mesenchymal stem cells prevents nephropathy in diabetic rats by ameliorating the inflammatory microenvironment

Y Li, J Liu, G Liao, J Zhang… - International …, 2018 - spandidos-publications.com
Diabetic nephropathy (DN) is a major complication of diabetes and represents the leading
cause of end-stage renal disease. Mesenchymal stem cell (MSC) treatment has been …

Assessment of intravenous adipose-derived allogeneic mesenchymal stem cells for the treatment of feline chronic kidney disease: a randomized, placebo-controlled …

JM Quimby, TL Webb, E Randall… - Journal of feline …, 2016 - journals.sagepub.com
Objectives Feline chronic kidney disease (CKD) is characterized by chronic tubulointerstitial
nephritis, and inflammation contributes to the progression of renal fibrosis. Mesenchymal …

Allogeneic mesenchymal stem cell transplantation for lupus nephritis patients refractory to conventional therapy

F Gu, D Wang, H Zhang, X Feng, GS Gilkeson… - Clinical …, 2014 - Springer
Allogeneic mesenchymal stem cell transplantation (MSCT) has been shown to be clinically
efficacious in the treatment of various autoimmune diseases. Here, we analyzed the role of …

Cell-based therapies for experimental chronic kidney disease: a systematic review and meta-analysis

DA Papazova, NR Oosterhuis… - Disease models & …, 2015 - journals.biologists.com
Cell-based therapy is a promising strategy for treating chronic kidney disease (CKD) and is
currently the focus of preclinical studies. We performed a systematic review and meta …