Sepsis remains one of the most common and lethal conditions globally. Currently, no
proposed target specific to sepsis improves survival in clinical trials. Thus, an in-depth …

With the rising incidences of antimicrobial resistance (AMR) and the diminishing options of
novel antimicrobial agents, it is paramount to decipher the molecular mechanisms of action …

Cationic antimicrobial peptides (CAMPs) are powerful molecules with antimicrobial,
antibiofilm and endotoxin-scavenging activities. These properties make CAMPs very …

Antimicrobial peptides (AMPs) are natural molecules that function within the innate immune
system to counteract pathogenic invasion and minimize the detrimental consequences of …

Antimicrobial peptides (AMPs) are a promising alternative to antibiotics in the fight against
multi-drug resistant and immune system-evading bacterial infections. Protegrins are porcine …

The binding of Host Defense Peptides (HDPs) to the endotoxin of Gram-negative bacteria
has important unsolved aspects. For most HDPs, it is unclear if binding is part of the …

A new series of hydantoin derivative dimers as potential broad-spectrum antibiotic agents is
designed and synthesized to combat ESKAPE pathogens. As membrane-active …