Latest insights into Marek's disease virus pathogenesis and tumorigenesis

LD Bertzbach, AM Conradie, Y You, BB Kaufer - Cancers, 2020 - mdpi.com
Marek's disease virus (MDV) infects chickens and causes one of the most frequent cancers
in animals. Over 100 years of research on this oncogenic alphaherpesvirus has led to a …

Latency and tumorigenesis in Marek's disease

V Nair - Avian diseases, 2013 - meridian.allenpress.com
Despite the remarkable progress in our understanding of Marek's disease (MD) and the
causative Marek's disease virus (MDV) biology, a number of major features of this complex …

Avian oncogenic herpesvirus antagonizes the cGAS-STING DNA-sensing pathway to mediate immune evasion

K Li, Y Liu, Z Xu, Y Zhang, D Luo, Y Gao, Y Qian… - PLoS …, 2019 - journals.plos.org
The cellular DNA sensor cGMP-AMP synthase (cGAS) detects cytosolic viral DNA via the
stimulator of interferon genes (STING) to initiate innate antiviral response. Herpesviruses are …

Distinct polymorphisms in a single herpesvirus gene are capable of enhancing virulence and mediating vaccinal resistance

AM Conradie, LD Bertzbach, J Trimpert… - PLoS …, 2020 - journals.plos.org
Modified-live herpesvirus vaccines are widely used in humans and animals, but field strains
can emerge that have a higher virulence and break vaccinal protection. Since the …

[HTML][HTML] Characterizaton of gamma delta T cells in Marek's disease virus (Gallid herpesvirus 2) infection of chickens

AMS Laursen, RR Kulkarni, K Taha-Abdelaziz… - Virology, 2018 - Elsevier
Immunity against Marek's disease (MD), caused by Gallid herpesvirus 2 (GaHV-2), in
chickens is mediated by both innate and adaptive responses. The present study evaluated …

Characterization of a unique novel LORF3 protein of duck plague virus and its potential pathogenesis

B Shen, P Ruan, A Cheng, M Wang, W Zhang… - Journal of …, 2023 - Am Soc Microbiol
Duck plague virus (DPV) is a high-morbidity fowl alphaherpesvirus that causes septicemic
lesions in various organs. Most DPV genes are conserved among herpesviruses, while a …

A Review on the Marek's Disease Outbreak and Its Virulence-Related meq Genovariation in Asia between 2011 and 2021

B Song, J Zeb, S Hussain, MU Aziz, E Circella… - Animals, 2022 - mdpi.com
Simple Summary Marek's disease is continuously causing an economic loss in Asia, despite
the wide use of vaccines in the last decade. This review aims at summarizing the outbreak …

Viral factors involved in Marek's disease virus (MDV) pathogenesis

LD Bertzbach, A Kheimar, FAZ Ali… - Current Clinical …, 2018 - Springer
Abstract Purpose of Review Marek's disease virus (MDV) is a highly oncogenic
alphaherpesvirus that causes various clinical symptoms including fatal lymphomas in …

P53 maintains gallid alpha herpesvirus 1 replication by direct regulation of nucleotide metabolism and ATP synthesis through its target genes

L Xu, Z Chen, Y Zhang, L Cui, Z Liu, X Li… - Frontiers in …, 2022 - frontiersin.org
P53, a well-known tumor suppressor, has been confirmed to regulate the infection of various
viruses, including chicken viruses. Our previous study observed antiviral effect of p53 …

Molecular evolution of Marek's disease virus (MDV) field strains in a 40-year time period

G Woźniakowski… - Avian …, 2014 - meridian.allenpress.com
Marek's disease (MD) presents a serious threat in poultry production. The disease has been
limited for over 40 yr by protective vaccination. The widely applied vaccination against MD is …