A review of the Residence Time Distribution (RTD) applications in solid unit operations
Y Gao, FJ Muzzio, MG Ierapetritou - Powder technology, 2012 - Elsevier
This review traces current applications of the residence time theory in various solid unit
operations. Besides reviewing recent experimental and simulation studies in the literature …
operations. Besides reviewing recent experimental and simulation studies in the literature …
Using residence time distribution in pharmaceutical solid dose manufacturing–A critical review
While continuous manufacturing (CM) of pharmaceutical solid-based drug products has
been shown to be advantageous for improving the product quality and process efficiency in …
been shown to be advantageous for improving the product quality and process efficiency in …
Using residence time distributions (RTDs) to address the traceability of raw materials in continuous pharmaceutical manufacturing
W Engisch, F Muzzio - Journal of pharmaceutical innovation, 2016 - Springer
Continuous processing in pharmaceutical manufacturing is a relatively new approach that
has generated significant attention. While it has been used for decades in other industries …
has generated significant attention. While it has been used for decades in other industries …
An integrated approach for dynamic flowsheet modeling and sensitivity analysis of a continuous tablet manufacturing process
F Boukouvala, V Niotis, R Ramachandran… - Computers & chemical …, 2012 - Elsevier
Manufacturing of powder-based products is a focus of increasing research in the recent
years. The main reason is the lack of predictive process models connecting process …
years. The main reason is the lack of predictive process models connecting process …
Characterizing continuous powder mixing using residence time distribution
Continuous powder mixing is an efficient alternative in high volume manufacturing of
powder-based products. A new method is communicated in this paper to determine the …
powder-based products. A new method is communicated in this paper to determine the …
Detailed modeling and process design of an advanced continuous powder mixer
A vertical in-line continuous powder mixing device (CMT–Continuous Mixing Technology)
has been modelled with the discrete element method (DEM) utilizing a calibrated cohesive …
has been modelled with the discrete element method (DEM) utilizing a calibrated cohesive …
Selection of an appropriate tracer to measure the residence time distribution (RTD) of continuous powder blending operations
Residence time distributions (RTDs) are quickly becoming an important component of the
quality control strategy for continuous manufacturing (CM) of pharmaceutical products …
quality control strategy for continuous manufacturing (CM) of pharmaceutical products …
Modeling of particulate processes for the continuous manufacture of solid-based pharmaceutical dosage forms
AJ Rogers, A Hashemi, MG Ierapetritou - Processes, 2013 - mdpi.com
The objective of this work is to present a review of computational tools and models for
pharmaceutical processes, specifically those for the continuous manufacture of solid dosage …
pharmaceutical processes, specifically those for the continuous manufacture of solid dosage …
Loss-in-weight feeding trials case study: pharmaceutical formulation
WE Engisch, FJ Muzzio - Journal of pharmaceutical innovation, 2015 - Springer
This article presents a case study of a continuous feeding strategy for five pharmaceutical
components (active pharmaceutical ingredient (API), Prosolv HD90, crospovidone …
components (active pharmaceutical ingredient (API), Prosolv HD90, crospovidone …
Explicit residence time distribution of a generalised cascade of continuous stirred tank reactors for a description of short recirculation time (bypassing)
The tanks-in-series model (TIS) is a popular model to describe the residence time
distribution (RTD) of non-ideal continuously stirred tank reactors (CSTRs) with limited back …
distribution (RTD) of non-ideal continuously stirred tank reactors (CSTRs) with limited back …