1, 2, 3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships

Z Xu, SJ Zhao, Y Liu - European journal of medicinal chemistry, 2019 - Elsevier
Anticancer agents are critical for the cancer treatment, but side effects and the drug
resistance associated with the currently used anticancer agents create an urgent need to …

Recent updates on 1, 2, 3-triazole-containing hybrids with in vivo therapeutic potential against cancers: A mini-review

S Zhao, J Liu, Z Lv, G Zhang, Z Xu - European Journal of Medicinal …, 2023 - Elsevier
Triazole moiety which is usually constructed by highly versatile, efficacious and selective
copper-catalyzed azide-alkyne cycloaddition not only can act as a linker to connect different …

Ramachary-Bressy-Wang [3+ 2] cycloaddition reaction: Synthesis of fully decorated 1, 2, 3-triazoles as potent anticancer and EGFR inhibitors

M Kumar, SK Nukala, NS Thirukovela… - Journal of Molecular …, 2022 - Elsevier
A general strategy was developed for the synthesis of new fully decorated 1, 2, 3-triazoles
(5a-m & 6a-e) containing coumarine and sulfonyl-benzimidazole from 3-(2-((1-methyl-1H …

Synthesis of [1,2,3]Triazolo-[1,5-a]quinoxalin-4(5H)-ones through Photoredox-Catalyzed [3 + 2] Cyclization Reactions with Hypervalent Iodine(III) Reagents

J Wen, W Zhao, X Gao, X Ren, C Dong… - The Journal of …, 2022 - ACS Publications
An efficient synthesis of a variety of [1, 2, 3] triazolo-[1, 5-a] quinoxalin-4 (5 H)-ones via a [3+
2] cyclization reaction by photoredox catalysis between quinoxalinones and hypervalent …

Microwave-assisted synthesis, molecular docking studies of 1, 2, 3-triazole-based carbazole derivatives as antimicrobial, antioxidant and anticancer agents

D Ashok, G Thara, BK Kumar, G Srinivas, D Ravinder… - RSC …, 2023 - pubs.rsc.org
Herein, a new series of N-substituted 1, 2, 3-triazolylmethyl indole derivatives 4 (a–u) was
synthesized by rationally incorporating a pharmacophoric active heterocyclic ring containing …

Benzothiazole-[1, 2, 3] triazolo [5, 1-a] isoindoles: Synthesis, anticancer activity, bioavailability and in silico studies against Gama-Tubulin protein

M Kumar, SK Nukala, M Ravinder, TM Krishna… - Journal of Molecular …, 2022 - Elsevier
We, herein, reported the CuI catalyzed synthesis of some novel fused benzothiazole-1, 2, 3-
triazole hybrids (5a-5o) in one-pot. The in vitro anticancer activity of these compounds …

Synthesis and biological evaluation of novel [1, 2, 3] triazolo-pyrrolo [1, 2-a] pyrido [4, 3-d] pyrimidines as EGFR targeting anticancer agents

SR Bandi, N Kavitha, SK Nukala… - Journal of Molecular …, 2023 - Elsevier
Herein, we synthesized some new fused [1, 2, 3] triazolo-pyrrolo [1, 2-a] pyrido [4, 3-d]
pyrimidines via click chemistry followed by carbon-carbon bond coupling as key approach …

Synthesis and Biological Evaluation of Benzo [d] thiazolyl‐Sulfonyl‐Benzo [4, 5] isothiazolo [2, 3‐c][1, 2, 3] triazole Derivatives as EGFR Targeting Anticancer Agents

E Ramya Sucharitha, S Kumar Nukala… - …, 2023 - Wiley Online Library
A one‐step procedure for the synthesis of new fused Benzo [d] thiazolo‐1, 2, 3‐triazoles (3 a–
3 h and 4 a–4 h) in good yields using sulfonylazides (2) and iodoalkyne (1) through from the …

Design, synthesis and biological evaluation of homoerythrina alkaloid derivatives bearing a triazole moiety as PARP-1 inhibitors and as potential antitumor drugs

S Li, X Li, T Zhang, MO Kamara, J Liang, J Zhu… - Bioorganic …, 2020 - Elsevier
A series of homoerythrina alkaloid derivatives containing a 1, 2, 3-triazole moiety as PARP-1
inhibitors were designed and synthesized. And their anti-proliferative activity was further …

One-pot synthesis, anticancer, EGFR and caspases assays of novel fused [1, 2, 3] triazolo-pyrrolo [2, 1-b] quinazolinones

N Udayasree, RB Haridasyam, R Palabindela… - Journal of Molecular …, 2025 - Elsevier
In this study, we designed and synthesized several novel fused [1, 2, 3] triazolo [4′, 5′: 3,
4] pyrrolo [2, 1-b] quinazolinone derivatives using a single [3+ 2] reaction cycloaddition …