Is immunotherapy in the future of therapeutic management of sarcomas?

O Clemente, A Ottaiano, G Di Lorenzo… - Journal of Translational …, 2021 - Springer
Sarcomas are rare, ubiquitous and heterogeneous tumors usually treated with surgery,
chemotherapy, target therapy, and radiotherapy. However, 25–50% of patients experience …

PDL1 expression is a poor-prognosis factor in soft-tissue sarcomas

F Bertucci, P Finetti, D Perrot, A Leroux, F Collin… - …, 2017 - Taylor & Francis
Soft-tissue sarcomas (STS) are a group of rare, heterogeneous, and aggressive tumors, with
high metastatic risk and relatively few efficient systemic therapies. In the quest for new …

Therapeutic response in musculoskeletal soft tissue sarcomas: evaluation by MRI

X Wang, MA Jacobs, L Fayad - NMR in Biomedicine, 2011 - Wiley Online Library
This article provides a literature review of the use of MRI in monitoring the treatment
response of soft tissue sarcomas. The basic classification and physiology of soft tissue …

Prognostic impact of lymphocytes in soft tissue sarcomas

SW Sorbye, T Kilvaer, A Valkov, T Donnem… - PLoS …, 2011 - journals.plos.org
Purpose The purpose of this study was to clarify the prognostic significance of lymphocyte
infiltration in soft tissue sarcomas (STS). Prognostic markers in potentially curable STS …

[HTML][HTML] Expression of hypoxic markers and their prognostic significance in soft tissue sarcoma

JI Kim, KU Choi, IS Lee, YJ Choi… - Oncology …, 2015 - spandidos-publications.com
Tumor hypoxia is significant in promoting tumor progression and resistance to therapy, and
hypoxia‑inducible factor 1α (HIF‑1α) is essential in the adaptive response of cells to hypoxia …

Evaluation of immune‑biomarker expression in high‑grade soft‑tissue sarcoma: HLA‑DQA1 expression as a prognostic marker

JY Bae, KU Choi, A Kim, SJ Lee… - Experimental and …, 2020 - spandidos-publications.com
High‑grade soft‑tissue sarcoma (STS) is a highly malignant neoplasm with a poor overall
prognosis. Numerous prognostic factors determine tumor progression and patient outcomes …

Prognostic impact of peritumoral lymphocyte infiltration in soft tissue sarcomas

SW Sorbye, TK Kilvaer, A Valkov, T Donnem… - BMC clinical …, 2012 - Springer
Background The purpose of this study was to clarify the prognostic significance of
peritumoral lymphocyte infiltration in the capsule of soft tissue sarcomas (STS). Multiple …

Prognostic significance of CD100 expression in soft tissue sarcoma

ES Ch'ng, Y Tomita, B Zhang, J He, Y Hoshida, Y Qiu… - Cancer, 2007 - Wiley Online Library
Abstract BACKGROUND. CD100, a class IV semaphorin, promotes angiogenesis, invasive
growth, proliferation, and antiapoptosis of cancer cells in vitro. The expression of CD100 in …

Combined vascular endothelial growth factor receptor/epidermal growth factor receptor blockade with chemotherapy for treatment of local, uterine, and metastatic soft …

W Ren, B Korchin, G Lahat, C Wei, S Bolshakov… - Clinical Cancer …, 2008 - AACR
Purpose: Soft tissue sarcoma (STS) is a rare heterogeneous malignancy. Overall survival
has been stagnant for decades, primarily because systemic therapies are ineffective versus …

Prognostic impact of CD57, CD68, M-CSF, CSF-1R, Ki67 and TGF-beta in soft tissue sarcomas

SW Sorbye, TK Kilvaer, A Valkov, T Donnem… - BMC clinical …, 2012 - Springer
Background Prognostic markers in curable STS may have the potential to guide therapy
after surgical resection. The purpose of this study was to clarify the prognostic impact of the …