Type 3 diabetes and its role implications in Alzheimer's disease

TT Nguyen, QTH Ta, TKO Nguyen… - International journal of …, 2020 - mdpi.com
The exact connection between Alzheimer's disease (AD) and type 2 diabetes is still in
debate. However, poorly controlled blood sugar may increase the risk of developing …

Metabolic dysregulation contributes to the progression of Alzheimer's disease

X Yan, Y Hu, B Wang, S Wang, X Zhang - Frontiers in neuroscience, 2020 - frontiersin.org
Alzheimer's disease (AD) is an incurable neurodegenerative disease. Numerous studies
have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis …

Effects of the insulin sensitizer metformin in Alzheimer disease: pilot data from a randomized placebo-controlled crossover study

AM Koenig, D Mechanic-Hamilton, SX Xie… - Alzheimer Disease & …, 2017 - journals.lww.com
Epidemiological studies have identified a robust association between type II diabetes
mellitus and Alzheimer disease (AD), and neurobiological studies have suggested the …

Long-acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or early-stage Alzheimer's disease dementia

A Claxton, LD Baker, A Hanson… - Journal of …, 2015 - content.iospress.com
Previous trials have shown promising effects of intranasally administered insulin for adults
with Alzheimer's disease dementia (AD) or amnestic mild cognitive impairment (MCI). These …

Insulin resistance and Alzheimer's disease: bioenergetic linkages

BJ Neth, S Craft - Frontiers in aging neuroscience, 2017 - frontiersin.org
Metabolic dysfunction is a well-established feature of Alzheimer's disease (AD), evidenced
by brain glucose hypometabolism that can be observed potentially decades prior to the …

Insulin resistance in Alzheimer's disease

LSS Ferreira, CS Fernandes, MNN Vieira… - Frontiers in …, 2018 - frontiersin.org
The epidemiological connection between diabetes, obesity, and dementia represents an
important public health challenge but also an opportunity to further understand these …

[HTML][HTML] Diabetes mellitus and cognitive impairments

E Saedi, MR Gheini, F Faiz, MA Arami - World journal of diabetes, 2016 - ncbi.nlm.nih.gov
There is strong evidence that diabetes mellitus increases the risk of cognitive impairment
and dementia. Insulin signaling dysregulation and small vessel disease in the base of …

Intranasal insulin for Alzheimer's disease

M Hallschmid - CNS drugs, 2021 - Springer
Brain insulin signaling contributes to memory function and might be a viable target in the
prevention and treatment of memory impairments including Alzheimer's disease. This short …

Effects of aerobic exercise on mild cognitive impairment: a controlled trial

LD Baker, LL Frank, K Foster-Schubert… - Archives of …, 2010 - jamanetwork.com
Objectives To examine the effects of aerobic exercise on cognition and other biomarkers
associated with Alzheimer disease pathology for older adults with mild cognitive impairment …

Type 3 diabetes is sporadic Alzheimer׳ s disease: mini-review

SM de la Monte - European neuropsychopharmacology, 2014 - Elsevier
Alzheimer׳ s disease (AD) is the most common cause of dementia in North America.
Growing evidence supports the concept that AD is a metabolic disease mediated by …