Functional genetic validation of key genes conferring insecticide resistance in the major African malaria vector, Anopheles gambiae
Resistance in Anopheles gambiae to members of all 4 major classes (pyrethroids,
carbamates, organochlorines, and organophosphates) of public health insecticides limits …
carbamates, organochlorines, and organophosphates) of public health insecticides limits …
Eliminating malaria vectors with precision-guided sterile males
RA Apte, AL Smidler, JJ Pai, ML Chow, S Chen… - Proceedings of the …, 2024 - pnas.org
Controlling the principal African malaria vector, the mosquito Anopheles gambiae, is
considered essential to curtail malaria transmission. However, existing vector control …
considered essential to curtail malaria transmission. However, existing vector control …
Mutagenesis of the orco odorant receptor co-receptor impairs olfactory function in the malaria vector Anopheles coluzzii
Mosquitoes rely heavily on their olfactory systems for host seeking, selection of oviposition
sites, and avoiding predators and other environmental dangers. Of these behaviors, the …
sites, and avoiding predators and other environmental dangers. Of these behaviors, the …
Tools for Anopheles gambiae Transgenesis
G Volohonsky, O Terenzi, J Soichot… - G3: Genes …, 2015 - academic.oup.com
Transgenesis is an essential tool to investigate gene function and to introduce desired
characters in laboratory organisms. Setting-up transgenesis in non-model organisms is …
characters in laboratory organisms. Setting-up transgenesis in non-model organisms is …
Discrete roles of Ir76b ionotropic coreceptor impact olfaction, blood feeding, and mating in the malaria vector mosquito Anopheles coluzzii
Anopheline mosquitoes rely on their highly sensitive chemosensory apparatus to detect
diverse chemical stimuli that drive the host-seeking and blood-feeding behaviors required to …
diverse chemical stimuli that drive the host-seeking and blood-feeding behaviors required to …
CRISPR-mediated germline mutagenesis for genetic sterilization of Anopheles gambiae males
Rapid spread of insecticide resistance among anopheline mosquitoes threatens malaria
elimination efforts, necessitating development of alternative vector control technologies …
elimination efforts, necessitating development of alternative vector control technologies …
Targeting mosquito X-chromosomes reveals complex transmission dynamics of sex ratio distorting gene drives
Engineered sex ratio distorters (SRDs) have been proposed as a powerful component of
genetic control strategies designed to suppress harmful insect pests. Two types of CRISPR …
genetic control strategies designed to suppress harmful insect pests. Two types of CRISPR …
Gene editing reveals obligate and modulatory components of the CO2 receptor complex in the malaria vector mosquito, Anopheles coluzzii
The sensitivity to volatile carbon dioxide (CO 2) produced by humans and other animals is a
critical component in the host preference behaviors of the malaria vector mosquito …
critical component in the host preference behaviors of the malaria vector mosquito …
Highly efficient site-specific mutagenesis in malaria mosquitoes using CRISPR
Anopheles mosquitoes transmit at least 200 million annual malaria infections worldwide.
Despite considerable genomic resources, mechanistic understanding of biological …
Despite considerable genomic resources, mechanistic understanding of biological …
Aedes aegypti CCEae3A carboxylase expression confers carbamate, organophosphate and limited pyrethroid resistance in a model transgenic mosquito
BC Poulton, F Colman, A Anthousi… - PLOS Neglected …, 2024 - journals.plos.org
Insecticide resistance is a serious threat to our ability to control mosquito vectors which
transmit pathogens including malaria parasites and arboviruses. Understanding the …
transmit pathogens including malaria parasites and arboviruses. Understanding the …