The focus of this article is to review the recent advances in proteome analysis of human
body fluids, including plasma/serum, urine, cerebrospinal fluid, saliva, bronchoalveolar …

CD146 is a cell adhesion molecule (CAM) that is primarily expressed at the intercellular
junction of endothelial cells. CD146 was originally identified as a tumor marker for …

DJ-1 is a member of the large and functionally diverse DJ-1/PfpI superfamily and has
homologs in nearly all organisms. Because of its connection to parkinsonism and cancer …

Mutations in the PARK7/DJ-1 gene are rare causes of autosomal-recessive hereditary
Parkinson's disease. Loss-of-function mutations lead to the characteristic selective …

DJ-1 is a cancer-and Parkinson's disease-associated protein that participates in different
intracellular signaling pathways to protect cells from toxic stresses. DJ-1 expression …

Broad-spectrum matrix metalloproteinase (MMP) inhibitors (MMPI) were unsuccessful in
cancer clinical trials, partly due to side effects resulting from limited knowledge of the full …

Proteomics has revealed that many proteins are present in unexpected cellular locations.
Moreover, it is increasingly recognized that proteins can translocate between intracellular …

Colorectal cancer (CRC) is the third most commonly diagnosed cancer in males and second
in females worldwide. Unfortunately 40–50% of patients already have metastatic disease at …

Purpose.: To compare the proteomic profiles of two categories of primary uveal melanoma
tissue samples; those from patients who have subsequently developed metastatic disease …

Metastasis remains a big barrier for the clinical treatment of colorectal cancer (CRC). Our
previous proteomics analysis identified DJ-1 as a potential metastasis biomarker of CRC. In …