Mutations have a profound effect on human health, particularly through an increased risk of
carcinogenesis and genetic disease. The strong correlation between mutagenesis and …

The Pig‐a (phosphatidylinositol glycan, Class A) gene codes for a catalytic subunit of the N‐
acetylglucosamine transferase complex involved in an early step of glycosylphosphatidyl …

There is a pressing requirement to define a hazard identification and risk management
strategy for nanomaterials due to the rapid growth in the nanotechnology industry and their …

LOCATE FREQUENTLY USED INFORMATION EASILY AND QUICKLYWorking in the
laboratory or office, you use a diverse assortment of basic information to design, conduct …

The in vivo Pig-a assay uses flow cytometry to measure phenotypic variants for antibody
binding to cell surface glycosylphosphatidylinositol (GPI)-anchored proteins. There is good …

The product of the phosphatidylinositol glycan complementation group A gene (Pig‐A) is
involved in the synthesis of glycosylphosphatidylinositol (GPI) anchors that link various …

The ability to effectively monitor gene mutation and micronucleated reticulocyte (MN-RET)
frequency in short-term and repeated dosing schedules was investigated using the recently …

In vivo mutation assays based on the Pig-a null phenotype, that is, the absence of cell
surface glycosylphosphatidylinositol (GPI) anchored proteins such as CD59, have been …

Abstract The International Life Sciences Institute (ILSI) Health and Environmental Sciences
Institute (HESI) Project Committee on the Relevance and Follow‐up of Positive Results in In …

The working group reached complete or majority agreement on many issues. Results from
TGR and in vivo comet assays for 91 chemicals showed they have similar ability to detect in …