Leveraging base-pair mammalian constraint to understand genetic variation and human disease

PF Sullivan, JRS Meadows, S Gazal, BDN Phan, X Li… - Science, 2023 - science.org
Thousands of genomic regions have been associated with heritable human diseases, but
attempts to elucidate biological mechanisms are impeded by an inability to discern which …
被引用次数：32 相关文章
[HTML] nih.gov

[HTML][HTML] Leveraging base-pair mammalian constraint to understand genetic variation and human disease

PF Sullivan, JRS Meadows, S Gazal… - Science (New York …, 2023 - ncbi.nlm.nih.gov
RESULTS: Using constraint calculated across placental mammals, 3.3% of bases in the
human genome are significantly constrained, including 57.6% of coding bases. Most …

Leveraging base-pair mammalian constraint to understand genetic variation and human disease

PF Sullivan, JRS Meadows, S Gazal… - … (New York, NY), 2023 - pubmed.ncbi.nlm.nih.gov
Thousands of genomic regions have been associated with heritable human diseases, but
attempts to elucidate biological mechanisms are impeded by an inability to discern which …

[引用][C] Leveraging base-pair mammalian constraint to understand genetic variation and human disease

PF Sullivan, JRS Meadows, S Gazal, BDN Phan… - …, 2023 - espace.library.uq.edu.au

Leveraging base-pair mammalian constraint to understand genetic variation and human disease

Zoonomia Consortium - Science, 2023 - providence.elsevierpure.com
Thousands of genomic regions have been associated with heritable human diseases, but
attempts to elucidate biological mechanisms are impeded by an inability to discern which …

Leveraging base-pair mammalian constraint to understand genetic variation and human disease

PF Sullivan, JRS Meadows, S Gazal, BDN Phan, X Li… - 2023 - digital.csic.es
Leveraging base-pair mammalian constraint to understand genetic variation and human
disease | DIGITAL.CSIC Skip navigation Logo pequeño DigitalCISC Producción CSIC Áreas e …

Leveraging base-pair mammalian constraint to understand genetic variation and human disease

PF Sullivan, J Meadows, S Gazal, BDN Phan, X Li… - Science, 2023 - diva-portal.org
Thousands of genomic regions have been associated with heritable human diseases, but
attempts to elucidate biological mechanisms are impeded by an inability to discern which …

Leveraging base-pair mammalian constraint to understand genetic variation and human disease

PF Sullivan, JR Meadows, S Gazal, BDN Phan, X Li… - Science, 2023 - par.nsf.gov
INTRODUCTION Thousands of genetic variants have been associated with human diseases
and traits through genome-wide association studies (GWASs). Translating these discoveries …

Leveraging Base Pair Mammalian Constraint to Understand Genetic Variation and Human Disease

PF Sullivan, JRS Meadows, S Gazal, BDN Phan, X Li… - bioRxiv, 2023 - biorxiv.org
Although thousands of genomic regions have been associated with heritable human
diseases, attempts to elucidate biological mechanisms are impeded by a general inability to …

Leveraging base-pair mammalian constraint to understand genetic variation and human disease.

PF Sullivan, JRS Meadows, S Gazal… - Science (New York …, 2023 - europepmc.org
Thousands of genomic regions have been associated with heritable human diseases, but
attempts to elucidate biological mechanisms are impeded by an inability to discern which …