… cell type, we then calculated the cell type specificity score s g,c , which represents the specificity
for gene g in cell type … measure of cell type specificity, was obtained by dividing the gene …

… Cellular involvement in RA pathogenesis. Identifying functionally relevant cell types that
could be involved in … Although genetic variants are inherited identically in various types of …

… categorizing the genetic architecture of many diseases and traits, we describe different types
of genetic architecture, how they can be assessed and why genetic architecture is important …

… opened on defining potential type 2 diabetes genes through genome-… genetic effects, the
impact of these genetic loci on diabetes risk, the potential mechanisms of action of the genes to …

… However, as with all complex morphological traits, our ability to identify and describe the
genetic architecture of the face is limited by our ability to accurately characterize its phenotypic …

… to risk as well as the contribution of complex gene-gene and gene-environment interactions
will likely be necessary to further improve our understanding of AD genetic architecture. …

… gene expression mediated through epigenetics. Further, we apply a computational approach
to prioritize the cell types … an in vitro or in vivo target cell type needs to be selected. Finally, …

… An epigenome-wide association study in 52 MZ twin pairs discordant for T1D in three
immune effector cell types: CD4+ T cells, CD19+ B cells, and CD14+CD16- monocytes used the …

… In the past decade, multiple efforts have been made to investigate the genetic architecture …
cell RNA sequencing, and high-throughput screens, will improve our understanding of genetic …

… The aetiology of T1D is hypothesized to involve genetic and environmental factors that result
in the T-cell mediated destruction of pancreatic beta cells. There is a strong genetic risk to …