Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease

J Park, R Shrestha, C Qiu, A Kondo, S Huang, M Werth… - Science, 2018 - science.org
… -cell RNA sequencing. On the basis of gene expression patterns, we infer that inherited kidney
diseases … manifestation originate from the same differentiated cell type. We also found that …

How many cell types are in the kidney and what do they do?

MS Balzer, T Rohacs, K Susztak - Annual review of physiology, 2022 - annualreviews.org
… Recently, our team has also performed single-cell analysis on a mouse chronic kidney
disease (CKD) model induced by FAN (18). We found a remarkable increase in immune …

Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease

H Liu, T Doke, D Guo, X Sheng, Z Ma, J Park, HMT Vy… - Nature …, 2022 - nature.com
… Next, we aimed to estimate kidney disease heritability mediated by DNA methylation and
gene expression using the recently developed mediated expression score regression (MESC) …

Stem cell options for kidney disease

C Hopkins, J Li, F Rae, MH Little - … of Pathology: A Journal of the …, 2009 - Wiley Online Library
cells or glomerular epithelial cells/podocytes? Do we need to introduce progenitors of these
cell types … do we need to provide support cells that encourage the existing renal parenchyma …

The cell biology of polycystic kidney disease

HC Chapin, MJ Caplan - Journal of Cell Biology, 2010 - rupress.org
… Polycystic kidney disease is a … kidney disease, which is attributable to mutations in the
PKD1 and PKD2 genes and which is characterized by perturbations of renal epithelial cell growth …

Identification of glomerular lesions and intrinsic glomerular cell types in kidney diseases via deep learning

C Zeng, Y Nan, F Xu, Q Lei, F Li, T Chen… - The Journal of …, 2020 - Wiley Online Library
Identification of glomerular lesions and structures is a key point for pathological diagnosis,
treatment instructions, and prognosis evaluation in kidney diseases. These time‐consuming …

Cell-based therapies for experimental chronic kidney disease: a systematic review and meta-analysis

DA Papazova, NR Oosterhuis… - Disease models & …, 2015 - journals.biologists.com
cell-based therapies in animal models of CKD. However, it is unclear which cell types or cell
… interventions, cell type or cell product, number of cells, administration route and read-out of …

T cells and autoimmune kidney disease

A Suarez-Fueyo, SJ Bradley, D Klatzmann… - Nature Reviews …, 2017 - nature.com
… The roles of different T-cell subsets in autoimmune kidney diseases are discussed below. …
cell types, the most important for kidney pathology are T H 17 cells, DN T cells and γδT cells 92 …

The role of inflammasomes in kidney disease

T Komada, DA Muruve - Nature Reviews Nephrology, 2019 - nature.com
… of inflammasomes in the pathophysiology of kidney diseases have generated great interest.
… of chronic kidney disease (CKD), acute kidney injury (AKI) and diabetic kidney disease (DKD…

The immune system and kidney disease: basic concepts and clinical implications

C Kurts, U Panzer, HJ Anders, AJ Rees - Nature Reviews Immunology, 2013 - nature.com
kidney diseases. Furthermore, the non-canonical function of NLRP3 during TGFβ1R signalling
that was first described in kidney disease not … study in different renal epithelial cell types. …