[HTML][HTML] Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets

Z Miao, MS Balzer, Z Ma, H Liu, J Wu… - Nature …, 2021 - nature.com
differentiation program could aid the understanding of kidney disease development. … ,
respectively, coinciding with the cellular differentiation program 41 . A large number of TFs …

[HTML][HTML] At the crossroads of the adipocyte and osteoclast differentiation programs: future therapeutic perspectives

S Muruganandan, AM Ionescu, CJ Sinal - International journal of …, 2020 - mdpi.com
differentiation program of hematopoietic stem cells (HSCs), and thus, hold therapeutic
potential under disease … the activation/repression of C/EBPβ target genes in HSCs [33,34]. In …

MicroRNA control of muscle development and disease

AH Williams, N Liu, E Van Rooij, EN Olson - Current opinion in cell biology, 2009 - Elsevier
… activates the myogenic differentiation program in conjunction with … target genes for miR-1
and 351 total predicted target genes for miR-133 using the microRNA target prediction program

[HTML][HTML] Productive lifecycle of human papillomaviruses that depends upon squamous epithelial differentiation

N Kajitani, A Satsuka, A Kawate, H Sakai - Frontiers in microbiology, 2012 - frontiersin.org
… ) target the stratified epidermis, and can causes diseasesdifferentiation programs. In this
review, we discuss the regulation of the HPV lifecycle controlled by the differentiation program

[HTML][HTML] The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells

II Ivanov, BS McKenzie, L Zhou, CE Tadokoro… - Cell, 2006 - cell.com
… its potential as a therapeutic target in inflammatory diseases. … that regulate Th17 cell
differentiation, we performed … Th1 (grown in IL-12) differentiation. In Th17 culture conditions, …

Single cell resolution regulatory landscape of the mouse kidney highlights cellular differentiation programs and renal disease targets

Z Miao, MS Balzer, Z Ma, H Liu, J Wu, R Shrestha… - bioRxiv, 2020 - biorxiv.org
differentiation program could aid the understanding of kidney disease development. …
investigation of kidney disease target genes and cell types using multi-omics mouse kidney data. …

[HTML][HTML] Nrf2 induction re-establishes a proper neuronal differentiation program in Friedreich's ataxia neural stem cells

P La Rosa, M Russo, J D'Amico, S Petrillo… - Frontiers in cellular …, 2019 - frontiersin.org
differentiation in neural stem cells (NSCs) isolated from the embryonic cortex of the Frataxin
Knockin/Knockout mouse, a disease … of the disease and to identify new targets for innovative …

MYOSLID Is a Novel Serum Response Factor–Dependent Long Noncoding RNA That Amplifies the Vascular Smooth Muscle Differentiation Program

J Zhao, W Zhang, M Lin, W Wu, P Jiang… - … , and vascular biology, 2016 - Am Heart Assoc
… Given that MYOSLID is a VSMC-selective lncRNA that apparently amplifies the VSMC
differentiation program, it could hold potential as a therapeutic target for treating vascular diseases

Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease

PAC Cloos, J Christensen, K Agger… - Genes & …, 2008 - genesdev.cshlp.org
… During cellular differentiation, the transcriptional program of cells is rapidly modulated to …
may constitute excellent drug targets for novel therapies to cancer and other human diseases. …

Polyglutamine expansion causes neurodegeneration by altering the neuronal differentiation program

G Abou-Sleymane, F Chalmel… - Human molecular …, 2006 - academic.oup.com
… ) belong to a group of inherited neurodegenerative diseases caused by polyglutamine (polyQ) …
to cause deregulation of a large subset of their target genes in both mouse models. To …