… (16,17) provide further evidence for a synaptic component to … genomic insights into
schizophrenia susceptibility in the context of gene expression and synaptic function in the …

… Quality control was performed on the cohorts separately according to standards developed
by the Psychiatric Genomics Consortium (PGC) 3 including SNP missingness < 0.05 (before …

… -stage genome-wide association study of up to 76,755 individuals with schizophrenia and
243,649 control individuals, we report common variant associations at 287 distinct genomic …

… These features raise several challenges for the development of rationally designed treatments.
First, since it is not currently possible to reliably predict who will develop schizophrenia, …

… of schizophrenia, primarily through large-scale genomic … of synaptic plasticity are particularly
affected in schizophrenia (7) … the potential strategies for developing novel therapies. The …

… It is expressed in the developing and adult human brain and … in the ACC in schizophrenia,
indicating that synaptic density … with schizophrenia was based on the largest available genome…

… and synaptic sensitivity, while unpublished data showing genome-wide significant association
to mir137 and to four other genes predicted to be silenced by microRNA 137 (encoded by …

… genetic architecture of schizophrenia and examine the evidence for synaptic involvement.
A … to other genome-wide significant signals, some play a role in brain development (miR137, …

… normal synaptic development and evidence from structural and functional imaging and
post-mortem studies that this is abnormal in people at risk and with schizophrenia. … Genome-wide …

… Furthermore, in a recent study of genomic convergence analysis of cerebellar cortices … by
which the synaptic alterations develop in schizophrenia. As synapse development and pruning …